• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tibolone

Tibolone

Product ID T3305
Cas No. 5630-53-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $67.80 In stock
100 mg $147.20 In stock
500 mg $338.00 In stock
1 g $525.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tibolone is a synthetic steroid hormone selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist depending on the tissue location. Tibolone exhibits anti-osteoporotic, vasodilatory, and anti-metastatic activities. Tibolone has estrogenic and androgenic activity and is used for hormone replacement therapy, preventing bone loss in postmenopausal women; it acts as an agonist at progesterone and androgen receptors. Tibolone and its various metabolites act on many enzymes; they inhibit STS, 17β-HSD1, and aromatase, and activate steroid sulfotransferase and 17β-HSD2. Tibolone produces vascular relaxation in coronary arteries as well. Additionally, this compound inhibits mammary carcinoma cell invasion, likely by decreasing activity of MMP9. Tibolone is an antagonist at mineralocorticoid and glucocorticoid receptors.

Product Info

Cas No.

5630-53-5

Purity

≥98%

Formula

C21H28O2

Formula Wt.

312.45

Chemical Name

(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one

IUPAC Name

(7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8, 9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

Synonym

Org-OD-14, Livial

Melting Point

163-169°C

Solubility

Soluble in ethanol, DMSO, and DMF.

Appearance

White or off-white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T3305 MSDS PDF

Info Sheet

T3305 Info Sheet PDF

References

Campisi R, Marengo FD. Cardiovascular effects of tibolone: a selective tissue estrogenic activity regulator. Cardiovasc Drug Rev. 2007 Summer;25(2):132-45. PMID: 17614936.

Raobaikady B, Parsons MF, Reed MJ, et al. Tibolone and its delta-4, 7alpha-methyl norethisterone metabolite are reversible inhibitors of human aromatase. J Steroid Biochem Mol Biol. 2007 May;104(3-5):154-60. PMID: 17467267.

Vanhoecke BW, Bracke ME, Kloosterboer HJ, et al. Tibolone and its metabolites inhibit invasion of human mammary carcinoma cells in vitro. Maturitas. 2006 Jun 20;54(3):229-37. PMID: 16581209.

Lund CO, Nilas L, Pedersen SH, et al. Tibolone and its metabolites acutely relax rabbit coronary arteries in vitro. Maturitas. 2004 Nov 15;49(3):179-88. PMID: 15488346.

Kloosterboer HJ. Tissue-selectivity: the mechanism of action of tibolone. Maturitas. 2004 Aug 30;48 Suppl 1:S30-40. PMID: 15337246.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1769

    Meropenem Trihydrate

    β-lactam carbapenem; penicillin binding protei...

    ≥98%
  • M1650

    Melanotan II

    Synthetis peptide, melanocortin analog; MCR ago...

    ≥98%
  • F4683

    Fluticasone Propionate

    β2-adrenergic agonist.

    ≥98%
  • Z4552

    ZLN005

    PPARγ coactivator-1α expression stimulator.

    ≥98%
  • G3454

    Ginsenoside Rb1

    Triterpene saponin found in species of Panax. <...

    ≥98%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • T2936

    Thioridazine Hydrochloride

    Piperadine phenothiazine; FIASMA, D1-5, histami...

    ≥98%
  • C2949

    Chlorpheniramine Maleate

    Alkylamine; histamine H1 antagonist, SERT and N...

    ≥98%
  • A4606

    Albendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥95%
  • A601022

    Apararenone

    Non-steroidal MRA

    ≥98%
  • A9801

    Azaperone

    Butyrophenone; α-adrenergic, D2, histamine ant...

    ≥98%
  • D3229

    7,8-Dihydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • A4577

    Alsterpaullone

    GSK-3 and CDK inhibitor.

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • A706840

    ARV-825

    Degrades of BET proteins.

    ≥99%
  • A0820

    N-Acetyl-S-(N′-benzylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, BITC derivative, antiox...

    ≥98%
  • M2409

    MGCD-0103

    HDAC inhibitor.

    ≥98%
  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%
  • K5604

    Kobe 0065

    Ras inhibitor.

    ≥99%
  • O4101

    Okadaic Acid

    Shellfish toxin produced by dinoflagellates and...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only