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Trichostatin A

Trichostatin A

Product ID T6933
Cas No. 58880-19-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $172.60 In stock
5 mg $615.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Trichostatin A is an inhibitor of class I and II HDACs that exhibits anticancer and immunomodulatory activities. Trichostatin A induces cell cycle arrest, increases phosphorylation of JNK, downregulates activity of MCM-2, induces apoptosis, and inhibits proliferation of colon cancer cells. Trichostatin A also enhances differentiation and activity of CD4+ Foxp3+ Treg cells. Additionally, trichostatin A alters mammalian RNA splicing.

Trichostatin A also alters RNA splicing.

Product Info

Cas No.

58880-19-6

Purity

≥98%

Formula

C17H22N2O3

Formula Wt.

302.37

Chemical Name

[R-(E,E)[-7-[4-(Dimethylamino)phenyl]-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide

IUPAC Name

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4, 6-dimethyl-7-oxohepta-2,4-dienamide

Synonym

TSA

Melting Point

150-151°C

Solubility

Soluble in lower alchols. Slightly soluble in chloroform, ethyl acetate, acetone and benzene.

Appearance

Beige Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

T6933 MSDS PDF

Info Sheet

T6933 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Liu Y, He G, Wang Y, et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. Toxicol Lett. 2013 Jul 31;221(1):23-30. PMID: 23770000.

Doñas C, Fritz M, Manríquez V, et al. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin Dev Immunol. 2013;2013:679804. PMID: 23737814.

Cecconi D, Donadelli M, Rinalducci S,et al. Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007 May;7(10):1644-53. PMID: 17443844.

Custom Order

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