Tubacin

Name: Tubacin
SKU: T8000
Availability: InStock

Product ID T8000

Cas No. 537049-40-4

Purity ≥96%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor that prevents α-tubulin deacetylation and displays anticancer activity. In cellular models of multiple myeloma and acute lymphoblastic leukemia, inhibition of HDAC6 inhibits cell motility and induces accumulation of ubiquitinated proteins, inducing apoptosis. Tubacin’s inhibitory action on HDAC also downregulates EGFR levels in a mutant renal epithelial cell line, indicating potential benefit as a treatment for polycystic kidney disease.

Product Info

Cas No.	537049-40-4
Purity	≥96%
Formula	C₄₁H₄₃N₃O₇S
Formula Wt.	721.86
IUPAC Name	N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1, 3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1, 3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Solubility	DMSO 100 mg/mL (138.53 mM) Water Insoluble Ethanol Insoluble
Appearance	white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T8000 MSDS PDF
Info Sheet	T8000 Info Sheet PDF
Brochures	Epigenetic Modifiers Booklet

References

Liu W, Fan LX, Zhou X, et al. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012;7(11):e49418. d PMID: 23152903.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma. 2011 Aug;52(8):1544-55. PMID: 21699378.

Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. PMID: 15937109.

Haggarty SJ, Koeller KM, Wong JC, et al. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. PMID: 12677000.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Tubacin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Vidarabine

Securinine

Palmitoyl-D,L-carnitine

Zolmitriptan

Laminin Peptide YIGSR

Doxepin Hydrochloride

Plasminogen Activator Inhibitor 1

Adrenocorticotropic Hormone (1-10), human

GDC-0980

N-Acetyl-D-Leucine

Ochratoxin A

Rosuvastatin Calcium

Formoterol Fumarate Dihydrate

Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

Pefloxacin Methanesulfonate Dihydrate

L-Allylglycine

Esculetin

Ac-DEVD-pNA

Paeoniflorin

Kenpaullone

Footer