LKT Labs

Biochemicals for Life Science Research

Tubacin

Tubacin

Product ID T8000
Cas No. 537049-40-4
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $367.00 In stock
5 mg $1,062.00 In stock
Bulk Quote

Quicklinks

Description

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor that prevents α-tubulin deacetylation and displays anticancer activity. In cellular models of multiple myeloma and acute lymphoblastic leukemia, inhibition of HDAC6 inhibits cell motility and induces accumulation of ubiquitinated proteins, inducing apoptosis. Tubacin’s inhibitory action on HDAC also downregulates EGFR levels in a mutant renal epithelial cell line, indicating potential benefit as a treatment for polycystic kidney disease.

Product Info

Cas No.

537049-40-4
Purity

≥96%
Formula

C41H43N3O7S

Formula Wt.

721.86
IUPAC Name

N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1, 3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1, 3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Solubility

DMSO 100 mg/mL (138.53 mM) Water Insoluble Ethanol Insoluble
Appearance

white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T8000 MSDS PDF
Info Sheet

T8000 Info Sheet PDF
Brochures

Epigenetic Modifiers Booklet

References

Liu W, Fan LX, Zhou X, et al. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012;7(11):e49418. d PMID: 23152903.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma. 2011 Aug;52(8):1544-55. PMID: 21699378.

Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. PMID: 15937109.

Haggarty SJ, Koeller KM, Wong JC, et al. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. PMID: 12677000.

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