• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tubacin

Tubacin

Product ID T8000
Cas No. 537049-40-4
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $367.30 In stock
5 mg $1,061.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor that prevents α-tubulin deacetylation and displays anticancer activity. In cellular models of multiple myeloma and acute lymphoblastic leukemia, inhibition of HDAC6 inhibits cell motility and induces accumulation of ubiquitinated proteins, inducing apoptosis. Tubacin’s inhibitory action on HDAC also downregulates EGFR levels in a mutant renal epithelial cell line, indicating potential benefit as a treatment for polycystic kidney disease.

Product Info

Cas No.

537049-40-4

Purity

≥96%

Formula

C41H43N3O7S

Formula Wt.

721.86

IUPAC Name

N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1, 3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1, 3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide

Solubility

DMSO 100 mg/mL (138.53 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T8000 MSDS PDF

Info Sheet

T8000 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Liu W, Fan LX, Zhou X, et al. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012;7(11):e49418. d PMID: 23152903.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma. 2011 Aug;52(8):1544-55. PMID: 21699378.

Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. PMID: 15937109.

Haggarty SJ, Koeller KM, Wong JC, et al. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. PMID: 12677000.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5472

    Ansamitocin P3

    Microtubule depolymerization inhibitor.

    ≥70% (P3), Total Ansamitocins ≥95%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • L8009

    D-Luciferin 1-(4,5-dimethoxy-2-nitrophenyl) Ethyl Ester

    Cell-membrane permeable heterocyclic light-emit...

    ≥95%
  • P0245

    Palmatine Chloride Hydrate

    Isoquinoline alkaloid found in Corydalis, Phell...

    ≥96%
  • C9773

    L-Cystine

    Endogenous amino acid, forms disulfide bridges ...

    ≥98%
  • B1955

    Benztropine Mesylate

    DAT inhibitor.

    ≥99%
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • SC7056

    Snake venom – Crotalus durissus terrificus

    Snake venom found in Crotalus durrisus terrific...

    ≥98%
  • T564093

    (+)-δ-Tocopherol

    Vitamin E component

    ≥98%
  • I7478

    Istradefylline

    Adenosine A2A antagonist.

    ≥99%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • S8049

    S-Sulforaphene

    Isothiocyanate found in cruciferous vegetables....

    ≥98%
  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • A4515

    Alendronate Monosodium Trihydrate

    Bisphosphonate.

    ≥98%
  • E537334

    Enniatin B

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • R2811

    Recombinant HIV-1 gp-41

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • P0255

    Pantoprazole

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%
  • D0375

    Dasatinib Monohydrate

    Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only