• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tubacin

Tubacin

Product ID T8000
Cas No. 537049-40-4
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $367.30 In stock
5 mg $1,061.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor that prevents α-tubulin deacetylation and displays anticancer activity. In cellular models of multiple myeloma and acute lymphoblastic leukemia, inhibition of HDAC6 inhibits cell motility and induces accumulation of ubiquitinated proteins, inducing apoptosis. Tubacin’s inhibitory action on HDAC also downregulates EGFR levels in a mutant renal epithelial cell line, indicating potential benefit as a treatment for polycystic kidney disease.

Product Info

Cas No.

537049-40-4

Purity

≥96%

Formula

C41H43N3O7S

Formula Wt.

721.86

IUPAC Name

N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1, 3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1, 3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide

Solubility

DMSO 100 mg/mL (138.53 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T8000 MSDS PDF

Info Sheet

T8000 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Liu W, Fan LX, Zhou X, et al. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012;7(11):e49418. d PMID: 23152903.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma. 2011 Aug;52(8):1544-55. PMID: 21699378.

Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. PMID: 15937109.

Haggarty SJ, Koeller KM, Wong JC, et al. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. PMID: 12677000.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T286161

    Theaflavin

    Polyphenolic compound present in black tea.

    ≥98%
  • N1721

    Nefiracetam

    Pyrrolidone; NMDA and mGluR5 agonist, N-type an...

    ≥98%
  • T6832

    Triamcinolone Acetonide

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • T1298

    TDZD-8

    GSK-3β inhibitor.

    ≥98%
  • O4417

    Oleanolic Acid

    Triterpenoid found in Vigna angularis and Trigo...

    ≥98%
  • M1679

    Methysticin

    Kavalactone originally found in Piper methystic...

    ≥98%
  • N3450

    Nimesulide

    NSAID; COX-2 inhibitor.

    ≥98%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • R8179

    Rutaecarpine, synthetic

    Found in Evodia rutaecarpa; potential cAMP, 3β...

    ≥98%
  • T2668

    TGR5 Receptor Agonist

    TGR5 agonist.

    ≥99%
  • A9912

    AZD-7762 Hydrochloride

    CHK1 inhibitor.

    ≥98%
  • I7746

    1-Isothiocyanato-7-(methylsulfenyl)-heptane

    ITC, erucin analog.

    ≥98%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%
  • B3577

    Bitertanol

    Pesticide; demethylation inhibitor.

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • S0072

    5S rRNA modificator

    Electrophile used in 2’-hydroxyl acylation of...

    ≥98%
  • G7340

    GSK-126

    EZH2 HMT inhibitor.

    ≥98%, ≥99%ee
  • I5414

    Indapamide

    Thiazide-like diuretic; Kv7.1 and minK K+ chann...

    ≥98%
  • O4556

    Olomoucine

    Purine derivative; CDK inhibitor.

    ≥98%
  • E5217

    β-Endorphin, human

    Endogenous opioid peptide; μOR agonist.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only