LKT Labs

Biochemicals for Life Science Research

Urocortin III, human

Urocortin III, human

Product ID U6859
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $158.00 In stock
1 mg $289.00 In stock
2.5 mg $593.00 In stock
Bulk Quote

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Description

Urocortin III is an endogenous peptide ligand and member of the corticotropin-releasing factor (CRF) family; it binds and activates CRF type 2 receptors. Urocortin III is expressed primarily in brain regions such as the hypothalamus (specifically the pituitary gland), but is also present in heart, kidney (adrenal glands), and gastrointestinal tissues. Urocortin III modulates stress responses and exhibits anorexigenic, anxiogenic, anxiolytic, and positive inotropic effects across a wide variety of in vivo models.

Product Info

Purity

≥95%
Formula

C185H307N53O50S2
Formula Wt.

4137.96
Synonym

UCN 3
Solubility

Insoluble in water. Soluble in DMSO.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

U6859 MSDS PDF
Info Sheet

U6859 Info Sheet PDF

References

Bagosi Z, Csabafi K, Palotai M, et al. The interaction of Urocortin II and Urocortin III with amygdalar and hypothalamic cotricotropin-releasing factor (CRF)--reflections on the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Neuropeptides. 2013 Oct;47(5):333-8. PMID: 23932308.

Takahashi K, Totsune K, Murakami O, et al. Urocortins as cardiovascular peptides. Peptides. 2004 Oct;25(10):1723-31. PMID: 15476939.

Suda T, Kageyama K, Sakihara S, et al. Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors. Peptides. 2004 Oct;25(10):1689-701. PMID: 15476936.

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