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Valacyclovir is an antiviral compound that is clinically used to treat infection of the Varicella-zoster virus. This compound is a prodrug for acyclovir. Valacyclovir also inhibits neuraminidase and displays efficacy against other viruses such as herpes simplex virus and HIV-1.
| Cas No. | 124832-27-5 |
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| Purity | ≥98% |
| Formula | C13H20N6O4 • HCl |
| Formula Wt. | 360.80 |
| Chemical Name | L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9- yl)methoxy]ethyl ester hydrochloride |
| IUPAC Name | 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate;hydrochloride |
| Synonym | Valacyclovir hydrochloride, BW-256U87 |
| Melting Point | 159-162°C |
| Solubility | Soluble in water (170 mg/mL), DMSO (14 mg/mL). Slightly soluble in ethanol (<1 mg/mL), methanol. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Gupta D, Varghese Gupta S, Dahan A, et al. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue. Mol Pharm. 2013 Feb 4;10(2):512-22. PMID: 23244438.
Roxby AC, Liu AY, Drake AL, et al. Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir. AIDS Res Hum Retroviruses. 2013 Jan;29(1):94-8. PMID: 22852760.
Andrei G, Snoeck R. Emerging drugs for varicella-zoster virus infections. Expert Opin Emerg Drugs. 2011 Sep;16(3):507-35. PMID: 21699441.