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Transient receptor potential vanilloid 1 (TRPV1) channels are activated by heat, proton, endovanilloids, endocannabinoids, and inflammatory mediators. TRPV1 is also considered the capsaicin receptor; it modulates neurotransmission and pain/nociceptive signaling. TRPV1 is expressed on neurons in arteries, blood vessels, skin tissues, and in the brain. Activation of TRPV1 may result in skeletal muscle constriction and arterial vasoconstriction.
| Purity | ≥95% |
|---|---|
| Formula | C75H118N18O28S2 |
| Formula Wt. | 1783.99 |
| Synonym | Transient receptor potential vanilloid 1, TRPV1, VR1, capsaicin receptor, Vanilloid Receptor Subtype 1 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Anwar IJ, Derbenev AV. TRPV1-dependent regulation of synaptic activity in the mouse dorsal motor nucleus of the vagus nerve. Front Neurosci. 2013 Dec 13;7:238. PMID: 24379754.
Tóth A, Czikora A, Pásztor ET, et al. Vanilloid Receptor-1 (TRPV1) Expression and Function in the Vasculature of the Rat. J Histochem Cytochem. 2013 Dec 5. [Epub ahead of print]. PMID: 24217926.
Kelly S, Chapman RJ, Woodhams S, et al. Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis. 2013 Oct 23. [Epub ahead of print]. PMID: 24152419.