LKT Labs

Biochemicals for Life Science Research

WWL70

WWL70

Product ID W894440
Cas No. 947669-91-2
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $86.00 Please Inquire
5 mg $251.00 Please Inquire
25 mg $966.00 Please Inquire
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Description

WWL70 is an inhibitor of the serine hydrolase alpha/beta hydrolase domain 6 (ABHD6). ABHD6 is able to hydrolyze 2-arachidonoyl glycerol(2-AG) to arachidonic acid. WWL70 inhibits this process from occurring, resulting in anti-inflammatory and anti-diabetic results. WWL70 was used to determine the role of ABHD6 in diet induced obese mice. Inhibition of ABHD6 resulted in lower weight gain and less incidence of diabetes in mice. In an LPS system, WWL70 was found to reduce the amount of pro-inflammatory prostaglandins.

Product Info

Cas No.

947669-91-2
Purity

≥95%
Formula

C27H23N3O3
Formula Wt.

437.50
Chemical Name

[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
IUPAC Name

[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
Solubility

10mM in DMSO

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

W894440 MSDS PDF
Info Sheet

W894440 Info Sheet PDF

References

Tanaka M, Moran S, Wen J et al. WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism. J Neuroinflammation. 2017 Jan 10;14(1):7. PMID: 28086912.

Zhao S, Mugabo Y, Ballentine G et al. alpha/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Cell Rep. 2016 Mar 29;14(12):2872-88. PMID: 26997277.

Alhouayek M, Masquelier J, Cani PD et al. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc Natl Acad Sci USA. 2013 Oct 22;110(43):17558-63. PMID: 24101490.

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