• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
ZSTK474

ZSTK474

Product ID Z7477
Cas No. 475110-96-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.00 In stock
10 mg $97.30 In stock
25 mg $175.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ZSTK474 is an inhibitor of PI3K that exhibits anticancer chemotherapeutic, anti-inflammatory, and anti-arthritis activities. ZSTK474 suppresses expression of matrix metalloproteinases (MMPs), VEGF, and HIF-1α, inhibiting migration, invasion, and adhesive capability of prostate cancer cells. ZSTK474 also induces G1 phase cell cycle arrest without inducing apoptosis in vitro and inhibits tumor growth in vivo. ZSTK474 inhibits the production of prostaglandin E2 (PGE2) in fibroblast-like synovial cells in vitro. In vivo, this compound decreases production of IFN-γ and IL-17, decreases the number of circulating T cells, and inhibits the progression of arthritis.

Product Info

Cas No.

475110-96-4

Purity

≥98%

Formula

C19H21F2N7O2

Formula Wt.

417.41

IUPAC Name

4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine

Solubility

DMSO 21 mg/mL (50.31 mM) Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Z7477 MSDS PDF

Info Sheet

Z7477 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Zhao W, Guo W, Zhou Q, et al. In Vitro Antimetastatic Effect of Phosphatidylinositol 3-Kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells. Int J Mol Sci. 2013 Jun 28;14(7):13577-91. PMID: 23812078.

Haruta K, Mori S, Tamura N, et al. Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats. Inflamm Res. 2012 Jun;61(6):551-62. PMID: 22349137.

Dan S, Okamura M, Mukai Y, et al. ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo. Eur J Cancer. 2012 Apr;48(6):936-43. PMID: 22088482.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R1876

    all-trans-Retinol

    Diterpene component of vitamin A, differentiati...

    ≥95%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.

    ≥99%
  • H9613

    N-(4-Hydroxyphenyl)retinamide

    Retinol (vitamin A) analog, binds RBP4; Des1 in...

    ≥98%
  • C3251

    Cinnarizine

    FIASMA, L-type Ca2+ channel blocker, D2 antagon...

    ≥98%
  • L9609

    Lycopene

    Carotene pigment found in red and green fruits ...

    ≥90%
  • S1609

    Securinine

    Alkaloid found in Securinega; potential GABA-A ...

    ≥98%
  • M8007

    Mubritinib, Free Base

    EGFR2 inhibitor.

    ≥99%
  • I0901

    Icariin

    Flavonol glycoside originally found in Epimediu...

    ≥97%
  • T7158

    Tropicamide

    mAChR antaonist.

    ≥98%
  • D3431

    3,4-Dihydroxyphenyl Ethanol

    Polyphenol found in olive oil, antioxidant.

    ≥95%
  • S0381

    Sauvagine

    CRF-related peptide found in amphibians.

    ≥98%
  • A7203

    AS-703026

    MEK1/2 inhibitor.

    ≥98%
  • M3576

    Mitotane

    Diphenylmethane, inhibits secretion of cortisol...

    ≥98%
  • H3273

    Histatin 5

    Endogenous antimicrobial peptide, binds bacteri...

    ≥95%
  • G7342

    GSK-2126458

    p110α PI3K and mTOR inhibitor.

    ≥99%
  • S881011

    Swainsonine

    Antineoplastic immunomodulator.

    ≥98%
  • R0245

    Raltitrexed

    Folate analog; thymidylate synthase inhibitor.<...

    ≥98%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • R1806

    Rebamipide

    Quinolone, antioxidant.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only