• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
ZSTK474

ZSTK474

Product ID Z7477
Cas No. 475110-96-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.00 In stock
10 mg $97.30 In stock
25 mg $175.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ZSTK474 is an inhibitor of PI3K that exhibits anticancer chemotherapeutic, anti-inflammatory, and anti-arthritis activities. ZSTK474 suppresses expression of matrix metalloproteinases (MMPs), VEGF, and HIF-1α, inhibiting migration, invasion, and adhesive capability of prostate cancer cells. ZSTK474 also induces G1 phase cell cycle arrest without inducing apoptosis in vitro and inhibits tumor growth in vivo. ZSTK474 inhibits the production of prostaglandin E2 (PGE2) in fibroblast-like synovial cells in vitro. In vivo, this compound decreases production of IFN-γ and IL-17, decreases the number of circulating T cells, and inhibits the progression of arthritis.

Product Info

Cas No.

475110-96-4

Purity

≥98%

Formula

C19H21F2N7O2

Formula Wt.

417.41

IUPAC Name

4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine

Solubility

DMSO 21 mg/mL (50.31 mM) Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Z7477 MSDS PDF

Info Sheet

Z7477 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Zhao W, Guo W, Zhou Q, et al. In Vitro Antimetastatic Effect of Phosphatidylinositol 3-Kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells. Int J Mol Sci. 2013 Jun 28;14(7):13577-91. PMID: 23812078.

Haruta K, Mori S, Tamura N, et al. Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats. Inflamm Res. 2012 Jun;61(6):551-62. PMID: 22349137.

Dan S, Okamura M, Mukai Y, et al. ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo. Eur J Cancer. 2012 Apr;48(6):936-43. PMID: 22088482.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A6269

    Apremilast

    PDE4 inhibitor.

    ≥98%
  • B349921

    BIX-01294

    Specific inhibitor of histone methyltransferase...

    ≥99%
  • I4000

    Ikarugamycin

    Protein translation inhibitor.

    ≥98%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.

    ≥99%
  • M1826

    Meglumine

    Amino sugar, sorbitol derivative, used as a bul...

    ≥98%
  • P8169

    Purpurin

    Anthraquinone pigment found in madder root; O-a...

    ≥90%
  • E7357

    Esomeprazole Potassium

    (S) isomer of omeprazole; H+/K+ ATPase and MAO-...

    ≥98%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • S6019

    Speract

    Peptide, derived from egg outer envelope; K+ ch...

    ≥95%
  • E7329

    Ethoxyquin

    Quinoline, food preservative; HSP90 inhibitor.<...

    ≥90%
  • M9643

    Myelin Basic Protein (1-11), human

    Peptide antigen fragment

    ≥95%
  • C0149

    Calcitonin, salmon

    Endogenous neuropeptide hormone, lowers extrace...

    ≥98%
  • T0105

    Taxol C

    Taxane synthesis intermediate.

    ≥95%
  • O7377

    Osthole

    O-methylated coumarin; Ca2+ channel blocker.

    ≥98%
  • G5875

    Gossypol Acetic Acid

    Bcl-2, Bcl-xl, sialyl transferase inhibitor.

    ≥98%
  • B6807

    [Des-Arg9]-Bradykinin

    Natriuretic, vasodilatory peptide, bradykinin a...

    ≥95%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • A5130

    Amphotericin B

    Polyene, binds ergosterol and induces membrane ...

    ≥90%
  • R2353

    RF-NH2

    RF-amide peptide; potential GPR147 agonist, pot...

    ≥95%
  • S8009

    Substance P (7-11)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only