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ZSTK474

ZSTK474

Product ID Z7477
Cas No. 475110-96-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.00 In stock
10 mg $97.30 In stock
25 mg $175.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ZSTK474 is an inhibitor of PI3K that exhibits anticancer chemotherapeutic, anti-inflammatory, and anti-arthritis activities. ZSTK474 suppresses expression of matrix metalloproteinases (MMPs), VEGF, and HIF-1α, inhibiting migration, invasion, and adhesive capability of prostate cancer cells. ZSTK474 also induces G1 phase cell cycle arrest without inducing apoptosis in vitro and inhibits tumor growth in vivo. ZSTK474 inhibits the production of prostaglandin E2 (PGE2) in fibroblast-like synovial cells in vitro. In vivo, this compound decreases production of IFN-γ and IL-17, decreases the number of circulating T cells, and inhibits the progression of arthritis.

Product Info

Cas No.

475110-96-4

Purity

≥98%

Formula

C19H21F2N7O2

Formula Wt.

417.41

IUPAC Name

4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine

Solubility

DMSO 21 mg/mL (50.31 mM) Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Z7477 MSDS PDF

Info Sheet

Z7477 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Zhao W, Guo W, Zhou Q, et al. In Vitro Antimetastatic Effect of Phosphatidylinositol 3-Kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells. Int J Mol Sci. 2013 Jun 28;14(7):13577-91. PMID: 23812078.

Haruta K, Mori S, Tamura N, et al. Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats. Inflamm Res. 2012 Jun;61(6):551-62. PMID: 22349137.

Dan S, Okamura M, Mukai Y, et al. ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo. Eur J Cancer. 2012 Apr;48(6):936-43. PMID: 22088482.

Custom Order

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