Sphingosine-1-Phosphate

Name: Sphingosine-1-Phosphate
SKU: S6130
Availability: InStock

Product ID S6130

Cas No. 26993-30-6

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Sphingosine-1-phosphate (S1P) is an endogenous signaling sphingolipid produced from metabolism of ceramides. S1P binds the S1P receptor and may inhibit HDACs. S1P exhibits neuroprotective activity as well as both pro-inflammatory and anti-inflammatory properties, depending on the model. S1P increases neuron viability and upregulates expression of Bcl-2 and Bcl-xl, inhibiting glucose deprivation stress. S1P upregulates expression of PAR4, promoting cell migration and COX-2 expression in vitro. Clinically, S1P preserves fertility and gonadal function in subjects exposed to cytotoxic agents such as chemotherapeutic compounds.

Product Info

Cas No.	26993-30-6
Purity	≥98%
Formula	C₁₈H₃₈NO₅P
Formula Wt.	379.47
Chemical Name	4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-
IUPAC Name	[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate InChI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16- 24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22, 23)/b15-14+/t17-,18+/m0/s1
Synonym	D-erythro-Sphingosine-1-phosphate
Melting Point	155°C
Solubility	Soluble in methanol.
Appearance	White Solid

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	S6130 MSDS PDF
Info Sheet	S6130 Info Sheet PDF

References

Czubowicz K, Cieślik M, Pyszko J, et al. Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival. Mol Neurobiol. 2014 Jul 24. [Epub ahead of print]. PMID: 25056275.

Mahajan-Thakur S, Sostmann BD, Fender AC, et al. Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. J Leukoc Biol. 2014 Jul 2. [Epub ahead of print]. PMID: 24990321.

Nguyen-Tran DH, Hait NC, Sperber H, et al. Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. Dis Model Mech. 2014 Jan;7(1):41-54. PMID: 24077965.

Zelinski MB, Murphy MK, Lawson MS, et al. In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates. Fertil Steril. 2011 Mar 15;95(4):1440-5.e1-7. PMID: 21316047.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Sphingosine-1-Phosphate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

RKI-1447

SB-431542

Cefazolin

Vincristine Sulfate

Rifaximin

1-Isothiocyanato-7-(methylsulfenyl)-heptane

CAY10505

SB-590885

Apremilast

L-Ornithine Hydrochloride

L-Theanine

Mastoparan X

Pimobendan

Arformoterol Tartrate

Epothilone B

(±)-Goitrin

10,13-Bissidechain Paclitaxel

Fumagillin

Enalapril Maleate

PAC-1

Footer