Loratadine

Name: Loratadine
SKU: L5767
Availability: InStock

Product ID L5767

Cas No. 79794-75-5

Purity ≥98%

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Description

Loratadine is a non-sedating antihistaminergic that acts as an antagonist at histamine H1 receptors that exhibits anti-inflammatory, anti-allergic, anti-asthma, and anticancer chemotherapeutic activities. Loratadine is clinically used to treat allergic rhinitis, chronic idiopathic urticaria, and asthma. In vivo, loratadine inhibits growth of colon cancer xenografts through decreases expression of cyclin B1 and Chk1, the induction of G2/M phase cell cycle arrest, and direct damage to DNA. Loratadine also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	79794-75-5
Purity	≥98%
Formula	C₂₂H₂₃ClN₂O₂
Formula Wt.	382.88
Chemical Name	4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta- [1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
IUPAC Name	ethyl 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2, 4-b]pyridin-11-ylidene)piperidine-1-carboxylate
Synonym	Claritin, Lisino
Melting Point	134-136°C
Solubility	Soluble in DMSO (26mg/mL). Insoluble in water.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L5767 MSDS PDF
Info Sheet	L5767 Info Sheet PDF

References

Soule BP, Simone NL, DeGraff WG, et al. Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. Radiat Oncol. 2010 Feb 3;5:8. PMID: 20128919.

DuBuske LM. Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. Expert Opin Pharmacother. 2005 Nov;6(14):2511-23. PMID: 16259582.

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Loratadine

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