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Vorinostat

Vorinostat

Product ID V5734
Cas No. 149647-78-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $97.70 In stock
250 mg $147.20 In stock
1 g $375.60 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

Vorinostat, also known as suberoylanilide hydroxamic acid, is a HDAC inhibitor that prevents the deacetylation of histones, therefore altering chromatin structure and inhibiting gene expression. In vitro, vorinostat promotes cell cycle arrest, induces apoptosis, and inhibits cellular proliferation. This compound is effective when administered with other synergistic treatments in glioblastoma stem-like cells and is currently in clinical trials as a potential treatment for a variety of gliomas. Additionally, vorinostat attenuates impairment of fear extinction in animal models and disrupts HIV latency in HIV-infected patients, suggesting it has additional antiviral benefit beyond its anticancer chemotherapeutic activity. Vorinostat also alters RNA splicing activity.

Product Info

Cas No.

149647-78-9

Purity

≥98%

Formula

C14H20N2O3

Formula Wt.

264.32

Chemical Name

N-hydroxy-N'-phenyl-octanediamide

IUPAC Name

N'-hydroxy-N-phenyloctanediamide

Synonym

suberoylanilide hydroxamic acid, SAHA, Zolinza

Melting Point

159-161C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V5734 MSDS PDF

Info Sheet

V5734 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Legartová S, Stixová L, Strnad H, et al. Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors. Epigenomics. 2013 Aug;5(4):379-96. PMID: 23895652.

Matsumoto Y, Morinobu S, Yamamoto S, et al. Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder. Psychopharmacology (Berl). 2013 Sep;229(1):51-62. PMID: 23584669.

Silva G, Cardoso BA, Belo H, et al. Vorinostat induces apoptosis and differentiation in myeloid malignancies: genetic and molecular mechanisms. PLoS One. 2013;8(1):e53766. PMID: 23320102.

Lee EQ, Puduvalli VK, Reid JM, et al. Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03. Clin Cancer Res. 2012 Nov 1;18(21):6032-9. PMID: 22923449.

Archin NM, Liberty AL, Kashuba AD, et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature. 2012 Jul 25;487(7408):482-5. PMID: 22837004.

Asklund T, Kvarnbrink S, Holmlund C, et al. Synergistic killing of glioblastoma stem-like cells by bortezomib and HDAC inhibitors. Anticancer Res. 2012 Jul;32(7):2407-13. PMID: 22753697.

Xu J, Sampath D, Lang FF, et al. Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures. J Neurooncol. 2011 Nov;105(2):241-51. PMID: 21598070.

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