Description
Paliperidone is an antipsychotic compound that inhibits D2 receptors and 5-HT2A receptors and is used to treat schizophrenia. Paliperidone also attenuates epinephrine- and serotonin-induced platelet aggregation.
Paliperidone
Product ID P0144
Cas No. 144598-75-4
Purity ≥97%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 144598-75-4 |
|---|---|
| Purity | ≥97% |
| Formula | C23H27FN4O3 |
| Formula Wt. | 426.48 |
| IUPAC Name | 3-[2-[4-(6-fluoro-1, 2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8, 9-tetrahydropyrido[1,2-a]pyrimidin-4-one |
| Synonym | 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, 9-OH-risperidone |
| Melting Point | 158-160°C |
| Solubility | DMSO: >5 mg/mL |
| Appearance | An offwhite or pale yellow powder |
Shipping and Storage
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Kozielska M, Johnson M, Pilla Reddy V, et al. Pharmacokinetic-pharmacodynamic modeling of the D2 and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res. 2012 Jul;29(7):1932-48. PMID: 22437487.
Gilday E, Nasrallah HA. Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia. Rev Recent Clin Trials. 2012 Feb;7(1):2-9. PMID: 22023179.
De Clerck F, Somers Y, Mannaert E, et al. In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. Clin Ther. 2004 Aug;26(8):1261-73. PMID: 15476907.