Protodioscin

Name: Protodioscin
SKU: P7057
Availability: InStock

Product ID P7057

Cas No. 55056-80-9

Purity ≥98%

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Description

Protodioscin is a saponin originally found in the rhizomes of several species of Dioscorea. Protodioscin exhibits cardioprotective, anti-hyperlipidemic, and anticancer activities. Protodioscin increases activities of the Na+/K+ ATPase and Ca2+/Mg2+ ATPase, protecting cardiomyocytes under anoxic conditions mimicking ischemic injury. In animal models, protodioscin decreases levels of triglycerides, LDL, and total cholesterol and increases levels of HDL in serum. In various cancer cell lines, metabolites of this compound exhibit anti-proliferative activity. Additionally, protodioscin downregulates levels of Bcl-2 and cyclin B1 and upregulates levels of Bax, inducing G2/M phase cell cycle arrest and apoptosis.

Product Info

Cas No.	55056-80-9
Purity	≥98%
Formula	C₅₀H₈₂O₂₂
Formula Wt.	1049.19
Chemical Name	(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[[(1S,2S,4S,6R,7S,8R,9S,12S,13R,16S)-6-hydroxy-7,9,13-trimethyl-6-[(3R)-3-methyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutyl]-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-en-16-yl]oxy]-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
IUPAC Name	(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[[(1S,2S,4S,6R,7S,8R,9S,12S,13R,16S)-6-hydroxy-7,9,13-trimethyl-6-[(3R)-3-methyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutyl]-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-en-16-yl]oxy]-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
Synonym	Furostanol I
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P7057 MSDS PDF
Info Sheet	P7057 Info Sheet PDF

References

Wang T, Choi RC, Li J, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6. PMID: 20509104.

Ning Z, Li YK, Zhou Y. Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. PMID: 20669680.

He X, Qiao A, Wang X, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids. 2006 Sep;71(9):828-33. PMID: 16797625.

Wang G, Chen H, Huang M, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006 Sep 8;241(1):102-9. PMID: 16458429.

Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 2003 Jun;21(3):389-93. PMID: 12901285.

Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med. 2002 Apr;68(4):297-301. PMID: 11988850.

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Protodioscin

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