LKT Labs

Biochemicals for Life Science Research

Tofacitinib Citrate

Product ID T5720
Cas No. 540737-29-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $110.00 In stock
25 mg $345.00 In stock
100 mg $1,250.00 In stock
Bulk Quote

Quicklinks

Description

Tofacitinib is an inhibitor of JAK1/2/3 that is clinically used to treat myelofibrosis and rheumatoid arthritis. Tofacitinib exhibits immunosuppressive, anti-inflammatory, and antiviral activities. In vitro, tofacitinib inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1, which in turn prevents induction of T-bet and generation of Th1 cells. In other cellular models, tofacitinib inhibits HIV replication and reactivation of latent HIV-1.

Product Info

Cas No.

540737-29-9
Purity

≥99%
Formula

C16H20N6O • C6H8O7
Formula Wt.

504.49
Chemical Name

3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt
IUPAC Name

2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
Synonym

CP-690550-10, Tasocitinib citrate salt
Solubility

Soluble in DMSO (100 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and 0.5% methylcellulose (30 mg/ml at 25 °C)
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5720 MSDS PDF
Info Sheet

T5720 Info Sheet PDF

References

Gavegnano C, Detorio M, Montero C, et al. Ruxolitinib and Tofacitinib are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation in Vitro. Antimicrob Agents Chemother. 2014 Jan 13. [Epub ahead of print]. PMID: 24419350.

Yamaoka K, Tanaka Y. Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib. Expert Opin Pharmacother. 2014 Jan;15(1):103-13. PMID: 4188100.

Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis Res Ther. 2011 May 25;13 Suppl 1:S5. PMID: 21624184.

Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43. PMID: 21383241.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4944

    Amlexanox

    Azoxanthone derivative; S100A12 and S100A13 inh...

    ≥99%
  • G7240

    GSK-2830371

    Wip1 inhibitor.

    ≥98%
  • C0243

    Calcitonin Gene Related Peptide (8-37), human

    Calcitonin-family peptide frgament, involved in...

    ≥95%
  • G3454

    Ginsenoside Rb1

    Triterpene saponin found in species of Panax. <...

    ≥98%
  • S0032

    Saikosaponin B1

    Saponin found in Bupleurum, Heteromorpha, and S...

    ≥98%
  • M1444

    MDL 29951

    GPR17 agonist, NMDA and fructose 1,6-bisphospha...

    ≥98%
  • P0145

    Palmitoyl-D,L-carnitine

    Long chain acylcarnitine involved in fatty acid...

    ≥98%
  • V9228

    VX-765

    NLRP3 and caspase-1 inhibitor.

    ≥98%
  • S4932

    SMI-4a

    Thiazolidine; Pim kinase inhibitor.

    ≥99%
  • S8046

    R-Sulforaphane, High Purity

    Naturally occuring isothiocyanate found in broc...

    ≥98%
  • G2873

    Growth Hormone Releasing Factor, sheep

    Endogenous peptide hormone, involved in growth ...

    ≥95%
  • C8500

    CV-65

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • A6970

    Artemether

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • M5877

    Motesanib Diphosphate

    VEGFR, PDGFR, c-Kit, RET inhibitor.

    ≥98%
  • E6783

    R-Equol

    Isoflavone, phytoestrogen found in soy

    ≥98%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • A5057

    Amoxicillin

    β-lactam; penicillin binding protein inhibitor...

    ≥99%
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • H9801

    Hyaluronic Acid Sodium (~1,000,000)

    Endogenous anionic non-sulfated glycosaminoglyc...
  • R3577

    Ritonavir

    HIV protease inhibitor.

    ≥98%