LKT Labs

Biochemicals for Life Science Research

Tofacitinib Citrate

Tofacitinib Citrate

Product ID T5720
Cas No. 540737-29-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $115.50 In stock
25 mg $362.30 In stock
100 mg $1,312.50 In stock
Bulk Quote

Quicklinks

Description

Tofacitinib is an inhibitor of JAK1/2/3 that is clinically used to treat myelofibrosis and rheumatoid arthritis. Tofacitinib exhibits immunosuppressive, anti-inflammatory, and antiviral activities. In vitro, tofacitinib inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1, which in turn prevents induction of T-bet and generation of Th1 cells. In other cellular models, tofacitinib inhibits HIV replication and reactivation of latent HIV-1.

Product Info

Cas No.

540737-29-9
Purity

≥99%
Formula

C16H20N6O • C6H8O7
Formula Wt.

504.49
Chemical Name

3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt
IUPAC Name

2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
Synonym

CP-690550-10, Tasocitinib citrate salt
Solubility

Soluble in DMSO (100 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and 0.5% methylcellulose (30 mg/ml at 25 °C)
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5720 MSDS PDF
Info Sheet

T5720 Info Sheet PDF

References

Gavegnano C, Detorio M, Montero C, et al. Ruxolitinib and Tofacitinib are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation in Vitro. Antimicrob Agents Chemother. 2014 Jan 13. [Epub ahead of print]. PMID: 24419350.

Yamaoka K, Tanaka Y. Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib. Expert Opin Pharmacother. 2014 Jan;15(1):103-13. PMID: 4188100.

Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis Res Ther. 2011 May 25;13 Suppl 1:S5. PMID: 21624184.

Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43. PMID: 21383241.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M3232

    Methylisoindigotin

    Indirubin derivative.

    ≥98%
  • D5690

    Doxazosin Mesylate

    Quinazoline; α1-adrenergic antagonist.

    ≥98%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • P0246

    Palomid 529

    mTOR inhibitor.

    ≥98%
  • L1780

    Levocetirizine Dihydrochloride

    L-isomer of cetirizine; histamine H1 antagonist...

    ≥98%
  • S8049

    S-Sulforaphene

    Isothiocyanate found in cruciferous vegetables....

    ≥98%
  • A0960

    Adrenocorticotropic Hormone (1-39), human

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • H1892

    Hexamethylene Bisacetamide

    HEXIM1 activator.

    ≥99%
  • T342710

    Tirzepatide

    GLP-1/GIP receptor co-agonist

    ≥98%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • N859614

    NVP-LDE225

    Smo inhibitor.

    ≥98%
  • P1635

    Peiminine

    Steroidal alkaloid found in Fritillaria; M2 mAC...

    ≥98%
  • B6816

    Brefeldin A

    Lactone found in fungi such as Eupenicillium; g...

    ≥97%
  • N8561

    NVP-AEW541

    IGF-1R inhibitor.

    ≥98%
  • N800000

    NU-2058

    CDK1/2 inhibitor.

    ≥98%
  • C0273

    Casin

    Cdc42 GTPase inhibitor.

    ≥97%
  • S8253

    Sunitinib Malate

    Indoline; PDGFR, VEGFR, c-KIT, FLT3, mTORC1 inh...

    ≥98%
  • C324091

    Ciclesonide

    Corticosteroid

    ≥98%
  • I5414

    Indapamide

    Thiazide-like diuretic; Kv7.1 and minK K+ chann...

    ≥98%
  • E4416

    Eledoisin

    Peptide, substance P analog; NK agonist.

    ≥95%