• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tofacitinib Citrate

Tofacitinib Citrate

Product ID T5720
Cas No. 540737-29-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $115.50 In stock
25 mg $362.30 In stock
100 mg $1,312.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tofacitinib is an inhibitor of JAK1/2/3 that is clinically used to treat myelofibrosis and rheumatoid arthritis. Tofacitinib exhibits immunosuppressive, anti-inflammatory, and antiviral activities. In vitro, tofacitinib inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1, which in turn prevents induction of T-bet and generation of Th1 cells. In other cellular models, tofacitinib inhibits HIV replication and reactivation of latent HIV-1.

Product Info

Cas No.

540737-29-9

Purity

≥99%

Formula

C16H20N6O • C6H8O7

Formula Wt.

504.49

Chemical Name

3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt

IUPAC Name

2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

Synonym

CP-690550-10, Tasocitinib citrate salt

Solubility

Soluble in DMSO (100 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and 0.5% methylcellulose (30 mg/ml at 25 °C)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5720 MSDS PDF

Info Sheet

T5720 Info Sheet PDF

References

Gavegnano C, Detorio M, Montero C, et al. Ruxolitinib and Tofacitinib are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation in Vitro. Antimicrob Agents Chemother. 2014 Jan 13. [Epub ahead of print]. PMID: 24419350.

Yamaoka K, Tanaka Y. Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib. Expert Opin Pharmacother. 2014 Jan;15(1):103-13. PMID: 4188100.

Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis Res Ther. 2011 May 25;13 Suppl 1:S5. PMID: 21624184.

Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43. PMID: 21383241.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C3246

    Cilostazol

    Quinoline; PDE 3B inhibitor.

    ≥98%
  • N9874

    Nystatin

    Polyene macrolide, induces pore formation in fu...

    4400u/mg
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • B3373

    Bis(aziridinyl)methylamino Phosphine Sulfide

    Insect sterilizer; mutagenic.

    ≥98%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • D3210

    Diclofenac free acid

    Somewhat selective in inhibiting COX-2 over COX...

    ≥99%
  • B3320

    Bifonazole

    Imidazole; HMG-CoA reductase, 14-α demethylase...

    ≥98%
  • A5228

    Angiogenin

    Small protein, cleaves RNA.

    ≥98%
  • G3355

    Ginkgolide B

    Terpene lactone found in Ginkgo; GlyR antagonis...

    ≥98%
  • M9645

    Myelin Oligodendrocyte Glycoprotein (35-55), rat

    Oligodendrocyte antigen used to induce EAE.

    ≥95%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosp...

    ≥97%
  • G0250

    cGAMP Disodium [STING Ligand]

    Cyclic dinucleotide that detects cytosolic DNA ...

    ≥98%
  • L493400

    LMK-235

    Selective HDAC4 and HDAC5 inhibitor.

    ≥98%
  • T8153

    Tunicamycin

    Nucleoside antibiotic mixture; GlcNAc phosphotr...

    ≥98%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • G0048

    γ-Amino Butyric Acid

    Endogenous neurotransmitter; GABA agonist.

    ≥99%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • G7345

    GSK-2606414

    PERK inhibitor.

    ≥99%
  • N5767

    Norethindrone

    Steroid hormone, contraceptive; PR agonist.

    ≥98%
  • B6800

    Bradykinin Triacetate

    Natriuretic, vasodilatory peptide; B1/2 agonist...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only