17-α-Ethynylestradiol

Name: 17-α-Ethynylestradiol
SKU: E7731
Availability: InStock

Product ID E7731

Cas No. 57-63-6, 77538-56-8, 406932-93-2, 1050678-65-3

Purity ≥99%

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Description

17-α-ethynylestradiol is a synthetic estrogen receptor (ER) agonist clinically used in contraceptive medications. In pregnant rats, 17-α-ethynylestradiol decreases platelet activating factor acetylhydrolase activity, inducing premature birth. 17-α-ethynylestradiol also displays weak antioxidative activity in lipid peroxidation assays in liver microsomes. Both acute and chronic exposure of wildlife (particularly fish) to 17-α-ethynylestradiol leads to feminization of males (through the induction of vitellogenin production), inhibiting fertility.

Product Info

Cas No.	57-63-6, 77538-56-8, 406932-93-2, 1050678-65-3
Purity	≥99%
Formula	C₂₀H₂₄O₂
Formula Wt.	296.40
Chemical Name	(8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
IUPAC Name	(8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
Synonym	Ethinylestradiol
Melting Point	182-183°C
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	E7731 MSDS PDF
Info Sheet	E7731 Info Sheet PDF

References

Kidd KA, Blanchfield PJ, Mills KH, et al. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8897-901. PMID: 17517636.

Schultz IR, Skillman A, Nicolas JM, et al. Short-term exposure to 17 alpha-ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem. 2003 Jun;22(6):1272-80. PMID: 12785584.

Yasuda K, Furukawa M, Johnston JM. Effect of estrogens on plasma platelet-activating factor acetylhydrolase and the timing of parturition in the rat. Biol Reprod. 1996 Jan;54(1):224-9. PMID: 8838020.

Lacort M, Leal AM, Liza M, et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids. 1995 Feb;30(2):141-6. PMID: 7769970.

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17-α-Ethynylestradiol

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Description

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