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7-Methyl-6-mercaptopurine

7-Methyl-6-mercaptopurine

Product ID M1575
Cas No. 3324-79-6
Purity ≥87%
Product Unit SizeCostQuantityStock
10 mg $92.00 In stock
50 mg $204.30 In stock
100 mg $330.50 In stock
500 mg $901.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

7-Methyl-6-mercaptopurine is a thiopurine antimetabolite and derivative of 6-mercaptopurine; it exhibits immunosuppressive, anti-inflammatory, and anticancer chemotherapeutic activities. This compound is clinically used to treat inflammatory bowel disorder (IBD), Crohn’s disease, and leukemias and lymphomas. This compound suppresses metabolism of inosine monophosphate (IMP), inhibiting phosphoribosylpyrophosphate amidotransferase; this prevents synthesis of purines, DNA, and RNA.

Product Info

Cas No.

3324-79-6

Purity

≥87%

Formula

C6H6N4S

Formula Wt.

166.21

Chemical Name

1,7-dihydro-7-methyl-6H-Purine-6-thione

IUPAC Name

7-methyl-3H-purine-6-thione

Synonym

7-Methyl-6-thiopurine, 7-Methylpurine-6-thiol

Melting Point

286-288°C

Solubility

Soluble in DMSO.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M1575 MSDS PDF

Info Sheet

M1575 Info Sheet PDF

References

Bradford K, Shih DQ. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease. World J Gastroenterol. 2011 Oct 7;17(37):4166-73. PMID: 22072847.

Nielsen OH, Vainer B, Rask-Madsen J. Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther. 2001 Nov;15(11):1699-708. PMID: 11683683.

Lennard L, Welch JC, Lilleyman JS. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br J Clin Pharmacol. 1997 Nov;44(5):455-61. PMID: 9384462.

Custom Order

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