| Product Unit Size | Cost | Quantity | Stock |
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A-779 is an inhibitor of the Mas receptor. On its own, A-779 has no biological activity; however, through binding the Mas receptor, it inhibits angiotensin (1-7) signaling (preventing vasodilation and insulin sensitization) and inhibits some downstream insulin signaling.
| Cas No. | 159432-28-7 |
|---|---|
| Purity | ≥95% |
| Formula | C39H60N12O11 |
| Formula Wt. | 872.99 |
| IUPAC Name | L-α-Aspartyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Tao X, Fan J, Kao G, et al. Angiotensin-(1-7) attenuates angiotensin II-induced signaling associated with activation of a tyrosine phosphatase in Sprague-Dawley rats cardiac fibroblasts. Biol Cell. 2014 Mar 18. [Epub ahead of print]. PMID: 24641355.
Santos RA, Campagnole-Santos MJ, Baracho NC, et al. Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res Bull. 1994;35(4):293-8. PMID: 7850477.