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Amifostine Trihydrate

Amifostine Trihydrate

Product ID A4933
Cas No. 112901-68-5
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $85.20 In stock
100 mg $151.30 In stock
500 mg $529.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Amifostine is a thiol prodrug that exhibits antioxidative activity. Amifostine is co-administered with chemotherapeutics to detoxify their metabolites and scavenge for free radicals, protecting normal tissue and DNA against chemotherapy- or radiation-induced damage.

Product Info

Cas No.

112901-68-5

Purity

≥98%

Formula

C5H15N2O3PS • 3H2O

Formula Wt.

268.27

Chemical Name

Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate

IUPAC Name

2-(3-aminopropylamino)ethylsulfanylphosphonic acid

Synonym

Ethiofos, Gammaphos, SAPEP, Ethyol

Melting Point

160–161°C

Solubility

Soluble in water.

Appearance

White or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A4933 MSDS PDF

Info Sheet

A4933 Info Sheet PDF

References

Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434.

Lv W, Zhang M, Zhang Z, et al. Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines. Adv Exp Med Biol. 2013;789:195-201. PMID: 23852495.

Wozniak K, Gloc E, Morawiec Z, et al. Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells. Exp Oncol. 2008 Mar;30(1):22-8. PMID: 18438337.

Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. PMID: 17602063.

Custom Order

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