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Apamin

Apamin

Product ID A6002
Cas No. 24345-16-2
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $173.30 In stock
1 mg $204.80 In stock
2.5 mg $472.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Apamin is a peptide bee venom toxin that acts as an antagonist at K+ channels. Apamin inhibits small- and intermediate-conductance Ca2+-activated K+ (SK2/3, IK) channels; it blocks the pore region, preventing K+ ion transport and lowering the threshold for action potential development. Apamin exhibits neuroprotective and cognition enhancing benefits, improving visiospatial learning deficits in animal models undergoing a water maze task in an in vivo model of neurofibromatosis 1.

Product Info

Cas No.

24345-16-2

Purity

≥95%

Formula

C79H131N31O24S4

Formula Wt.

2027.37

Solubility

Soluble in water (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A6002 MSDS PDF

Info Sheet

A6002 Info Sheet PDF

References

Dalaklioglu S, Ozbey G. Role of different types of potassium channels in the relaxation of corpus cavernosum induced by resveratrol. Pharmacogn Mag. 2014 Jan;10(37):47-52. PMID: 24696545.

Kallarackal AJ, Simard JM, Bailey AM. The effect of apamin, a small conductance calcium activated potassium (SK) channel blocker, on a mouse model of neurofibromatosis 1. Behav Brain Res. 2013 Jan 15;237:71-5. PMID: 22983217.

Lamy C, Goodchild SJ, Weatherall KL, et al. Allosteric block of KCa2 channels by apamin. J Biol Chem. 2010 Aug 27;285(35):27067-77. PMID: 20562108.

Custom Order

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