• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AS-605240

AS-605240

Product ID A7204
Cas No. 648450-29-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.60 In stock
5 mg $127.70 In stock
10 mg $182.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AS-605240 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, and anti-diabetic activities. In animal models, AS-605240 inhibits the development of or reverses the progression of experimental autoimmune encephalitis (EAE). AS-605240 also inhibits the development of acute lung injury pathology in animal models through increasing levels of ROS, VEGF, and cytokines and decreasing infiltration of dendritic cells and expression of toll-like receptor 4 (TLR4).

Product Info

Cas No.

648450-29-7

Purity

≥98%

Formula

C12H7N3O2S

Formula Wt.

257.27

IUPAC Name

(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Synonym

AS605240

Solubility

DMSO 0.4 mg/mL (1.55 mM) Water Insoluble Ethanol Insoluble

Appearance

Light reddish powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7204 MSDS PDF

Info Sheet

A7204 Info Sheet PDF

References

Comerford I, Litchfield W, Kara E, et al. PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis. PLoS One. 2012;7(9):e45095. PMID: 23028778.

Azzi J, Moore RF, Elyaman W, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18. PMID: 22403300.

Kim DI, Kim SR, Kim HJ, et al. PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses. J Clin Immunol. 2012 Apr;32(2):340-51. PMID: 22198681.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C000078

    C-178

    STING inhibitor

    ≥99%
  • P0370

    Paromomycin Sulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • C0029

    Cafestol Oleate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • T0205

    3”,4”-Dehydropaclitaxel C

    Semi-synthetic taxane.

    ≥95%
  • L9600

    LY-2090314

    GSK-3 inhibitor.

    ≥98%
  • C9882

    Cytochalasin E

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • A9914

    AZD-8055

    mTOR inhibitor.

    ≥98%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • H9714

    L-5-Hydroxytryptophan

    Endogenous amino acid, precursor of 5-HT and me...

    ≥98%
  • U6859

    Urocortin III, human

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • A5133

    Amiloride Hydrochloride Dihydrate

    K+-sparing diuretic; ENaC and acid-sensing ion ...

    ≥98%
  • C9608

    Cycloastragenol

    Triterpene aglycone found in Radix Astragali; t...

    ≥98%
  • E5369

    Enrofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • C294458

    Chlorzoxazone

    Centrally acting muscle relaxant.

    ≥99%
  • K740640

    KSQ-4279

    USP1 inhibitor

    ≥98%
  • A0248

    BAM-12P

    Peptide, cleavage product of proenkephalin; κO...

    ≥95%
  • F4557

    Floxuridine

    5-Fluorouracil derivative, fluorinated pyrimidi...

    ≥98%
  • M568268

    Mogroside IV

    Triterpenoid

    ≥98%
  • D1849

    4′-Demethylepipodophyllotoxin

    Podophyllotoxin derivative found in Podophyllum...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only