• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AS-605240

AS-605240

Product ID A7204
Cas No. 648450-29-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.60 In stock
5 mg $127.70 In stock
10 mg $182.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AS-605240 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, and anti-diabetic activities. In animal models, AS-605240 inhibits the development of or reverses the progression of experimental autoimmune encephalitis (EAE). AS-605240 also inhibits the development of acute lung injury pathology in animal models through increasing levels of ROS, VEGF, and cytokines and decreasing infiltration of dendritic cells and expression of toll-like receptor 4 (TLR4).

Product Info

Cas No.

648450-29-7

Purity

≥98%

Formula

C12H7N3O2S

Formula Wt.

257.27

IUPAC Name

(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Synonym

AS605240

Solubility

DMSO 0.4 mg/mL (1.55 mM) Water Insoluble Ethanol Insoluble

Appearance

Light reddish powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7204 MSDS PDF

Info Sheet

A7204 Info Sheet PDF

References

Comerford I, Litchfield W, Kara E, et al. PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis. PLoS One. 2012;7(9):e45095. PMID: 23028778.

Azzi J, Moore RF, Elyaman W, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18. PMID: 22403300.

Kim DI, Kim SR, Kim HJ, et al. PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses. J Clin Immunol. 2012 Apr;32(2):340-51. PMID: 22198681.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • I8618

    Ivermectin

    Avermectin; glu-gated Cl- channel activator, Gl...

    ≥95%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • M0173

    Mastoparan X

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • G7345

    GSK-2606414

    PERK inhibitor.

    ≥99%
  • N0262

    Naphazoline Hydrochloride

    α1-adrenergic agonist.

    ≥97%
  • S8248

    Sulfamethoxazole

    Sulfonamide; PABA inhibitor.

    ≥98%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%
  • A5478

    Antipain Dihydrochloride

    Oligopeptide found in Actinomycetes; protease i...

  • P4782

    PluriSIn 1

    Stearoyl-coA desaturase 1 inhibitor.

    ≥98%
  • M7528

    α-Melanocyte Stimulating Hormone

    Endogenous peptide hormone derived from POMC, i...

    ≥98%
  • A1607

    AEBSF Hydrochloride

    Serine protease substrate/inhibitor.

    ≥98%
  • S822687

    Surfactin

    Amphiphilic properties

    ≥90% mixed isomers
  • E5220

    Enfuvirtide (T-20)

    Synthetic peptide derived from HIV-1; viral fus...

    ≥95%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • D582705

    Dorsomorphin Dihydrochloride

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • C3260

    Ciprofibrate

    Fibrate; PPARα agonist.

    ≥98%
  • H9717

    Hydroxyzine Dihydrochloride

    FIASMA, histamine H1 inverse agonist, 5-HT2A, D...

    ≥98%
  • R2711

    Recombinant HCV-Core Antigens

    Recombinant HIV core protein antigen fragment.<...

    ≥95%
  • C0156

    9-Nitro-20S-camptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only