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Balofloxacin is a fluoroquinolone antibiotic that displays strong antibacterial activity against gram-positive bacteria and weak antibacterial activity against gram-negative bacteria. Balofloxacin inhibits the supercoiling ability of bacterial DNA gyrase, and shows efficacy treating early and middle stages of infection by bacteria such as Mycoplasma pneumoniae in animal models.
| Cas No. | 151060-21-8 |
|---|---|
| Purity | ≥98% |
| Formula | C20H24FN3O4 • 2H2O |
| Formula Wt. | 425.45 |
| IUPAC Name | 1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4- oxoquinoline-3-carboxylic acid;dihydrate |
| Appearance | White to yellow crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Iwasaki H, Miyazaki S, Tsuji A, et al. In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone. Chemotherapy. 1995 Mar-Apr;41(2):100-12. PMID: 7758353.
Ito T, Kojima K, Koizumi K, et al. Inhibitory activity on DNA gyrase and intracellular accumulation of quinolones: structure-activity relationship of Q-35 analogs. Biol Pharm Bull. 1994 Jul;17(7):927-30. PMID: 8000379.
Gohara Y, Arai S, Akashi A, et al. In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae. Antimicrob Agents Chemother. 1993 Sep;37(9):1826-30. PMID: 8239590.
Ito T, Otsuki M, Nishino T. In vitro antibacterial activity of Q-35, a new fluoroquinolone. Antimicrob Agents Chemother. 1992 Aug;36(8):1708-14. PMID: 1329626.