Bupropion Hydrochloride

Name: Bupropion Hydrochloride
SKU: B8363
Availability: InStock

Product ID B8363

Cas No. 31677-93-7

Purity ≥98%

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Description

Bupropion is an antidepressant that is also commonly used as a smoking cessation aid. This compound has additional therapeutic potential, as it promotes modest weight loss, shows efficacy as an ADHD treatment, and may also be an effective treatment for neuropathic pain. Bupropion is a DA and NE reuptake inhibitor, decreasing the firing rate of NE neurons due to activation of their inhibitory somatodendritic α2-adrenoreceptors by circulating NE; bupropion’s effects on NE reuptake are somewhat stronger than its effects on DA reuptake. Additionally, bupropion is a noncompetitive antagonist at α3β2, α3β4, α4β2 nicotinic acetylcholine receptors (nAChRs), decreasing the probability of channel opening in closed nAChRs and accelerating desensitization in open nAChRs.

Product Info

Cas No.	31677-93-7
Purity	≥98%
Formula	C₁₃H₁₈ClNO • HCl
Formula Wt.	276.2
IUPAC Name	2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrochloride
Synonym	Wellbutrin
Melting Point	236.0-238.0
Solubility	50 mg/ml MeOH
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	B8363 MSDS PDF
Info Sheet	B8363 Info Sheet PDF

References

Shah TH, Moradimehr A. Bupropion for the treatment of neuropathic pain. Am J Hosp Palliat Care. 2010 Aug;27(5):333-6. PMID: 20185402.

Arias HR. Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions? Int J Biochem Cell Biol. 2009 Nov;41(11):2098-108. PMID: 19497387.

Li Z, Maglione M, Tu W, et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005 Apr 5;142(7):532-46. PMID: 15809465.

Miller DK, Sumithran SP, Dwoskin LP. Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine. J Pharmacol Exp Ther. 2002 Sep;302(3):1113-22. PMID: 12183670.

Dong J, Blier P. Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment. Psychopharmacology (Berl). 2001 Apr;155(1):52-7. PMID: 11374336.

Cantwell DP. ADHD through the life span: the role of bupropion in treatment. J Clin Psychiatry. 1998;59 Suppl 4:92-4. PMID: 9554326.

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Bupropion Hydrochloride

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Description

Product Info

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