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Buspirone is an azapirone anxiolytic that acts as a partial agonist at 5-HT1A receptors and α1-adrenergic receptors and an antagonist at D2/3/4 receptors. Buspirone is clinically used to treat anxiety. In animal models, buspirone inhibits MMPP-induced enhancements in memory acquisition and formation.
| Cas No. | 33386-08-2 |
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| Purity | ≥98% |
| Formula | C21H31N5O2 • HCl |
| Formula Wt. | 421.97 |
| Chemical Name | 8-[4-[4-(2-Pyrimidinyl)=1=piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
| IUPAC Name | 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7, 9-dione;hydrochloride |
| Synonym | Anisal, Axoren, Bespar, Buspinol, Narol |
| Melting Point | 201.5-202.5°C |
| Solubility | Soluble in water. |
| Appearance | White powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Navarrete A, Flores-Machorro FX, Téllez-Ballesteros RI, et al. Study on action mechanism of 1-(4-methoxy-2-methylphenyl)piperazine (MMPP) in acquisition, formation, and consolidation of memory in mice. Drug Dev Res. 2014 Mar;75(2):59-67. PMID: 24648132.
Loane C, Politis M. Buspirone: what is it all about? Brain Res. 2012 Jun 21;1461:111-8. PMID: 22608068.