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cGAMP Disodium [STING Ligand]

cGAMP Disodium [STING Ligand]

Product ID G0250
Cas No. 2407516-83-8, 849214-04-6 (free acid)
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $102.90 In stock
500 µg $299.30 In stock
1 mg $551.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

cGAMP is a cyclic dinucleotide that functions as an endogenous second messenger that detects cytosolic DNA and induces STING-dependent interferon type 1 responses. cGAMP exhibits immunostimulatory activity and acts as an adjuvant. This compound enhances adaptive immune responses by increasing antigen-specific IgG levels in vivo.

Product Info

Cas No.

2407516-83-8, 849214-04-6 (free acid)

Purity

≥98%

Formula

C20H24N10O13P2・Na2

Formula Wt.

718.37

Chemical Name

3',3'-cGAMP disodium

IUPAC Name

disodium;2-amino-9-[(1S,6R,8R,9R,10S,15R,17R,18R)-17-(6-aminopurin-9-yl)-9,18-dihydroxy-3,12-dioxido-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]-1H-purin-6-one

Synonym

cyclic (adenosine monophosphate-guanosine monophosphate), cyclic GMP-AMP, c-(GpAp), 3',3'-cGAMP

Solubility

Soluble in water.

Appearance

Crystalline solid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G0250 MSDS PDF

Info Sheet

G0250 Info Sheet PDF

References

Ma F, Li B, Liu SY, et al. Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS. J Immunol. 2015 Feb 15;194(4):1545-54. PMID: 25609843.

Škrnjug I, Guzmán CA, Rueckert C. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. Erratum in: PLoS One. 2015;10(3):e0123605. Ruecker, Christine [corrected to Rueckert, Christine]. PMID: 25295996.

Wu J, Sun L, Chen X, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. PMID: 23258412.

Custom Order

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