LKT Labs

Biochemicals for Life Science Research

Chlorpromazine Hydrochloride

Chlorpromazine Hydrochloride

Product ID C2947
Cas No. 69-09-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $78.00 In stock
25 g $109.00 In stock
100 g $325.00 In stock
Bulk Quote

Quicklinks

Description

Chlorpromazine is a phenothiazine that exhibits antipsychotic, antidepressant, anxiolytic, neuroprotective, and anticancer chemotherapeutic activities. Chlorpromazine inhibits D1/2/3/4 receptors, 5-HT1/2 receptors, α1/2-adrenergic receptors, and M1/2 muscarinic acetylcholine receptors (mAChRs). Chlorpromazine stabilizes misfolding motifs of prions, preventing oligomerization. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA). In vivo, chlorpromazine induces autophagy and apoptosis, inhibiting growth of glioma tumors.

Product Info

Cas No.

69-09-0
Purity

≥98%
Formula

C17H19ClN2S • HCl
Formula Wt.

355.33
Chemical Name

2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride
IUPAC Name

3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Synonym

Hebanil, Klorpromex, Largactil, Megaphen, Promacid, Chloractil, Sonazine, Marazine, Taroctyl, Torazina
Melting Point

179-180°C(dec.)
Solubility

Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C2947 MSDS PDF
Info Sheet

C2947 Info Sheet PDF

References

Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Shin SY, Lee KS, Choi YK, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. PMID: 23689352.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518-22. PMID: 6108081.

Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011 Oct;23(10):637-645. PMID: 21930594.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5285

    [Ile7]-Angiotensin III

    Peptide, derivative of AT III, cleavage product...

    ≥95%
  • T7003

    Trazodone Hydrochloride

    5-HT1A partial agonist, 5-HT2, histamine, α1/2...

    ≥98%
  • H9801

    Hyaluronic Acid Sodium (~1,000,000)

    Endogenous anionic non-sulfated glycosaminoglyc...
  • T7232

    S-Trityl-L-cysteine

    Organosulfur found in garlic; kinesin Eg5 inhib...

    ≥98%
  • G4434

    Gliotoxin

    Toxin produced by Aspergillus.

    ≥98%
  • D5612

    2-n-Dodecylfuran

    Furan derivative.

    ≥98%
  • K9200

    KX1-004

    Indole; Src inhibitor.

    ≥98%
  • B0109

    Bakuchiol

    Prenylated phenolic terpene found in various pl...

    ≥98%
  • N5072

    NMS-1286937

    PLK1 inhibitor.

    ≥98%
  • M5746

    Molsidomine

    NO donor; annexin A2 inhibitor.

    ≥98%
  • C760001

    CT-7001

    CDK7 inhibitor

    ≥99%
  • D1624

    Deflazacort

    Oxazoline; glucocorticoid agonist.

    ≥98%
  • F0150

    Famotidine

    Histamine H2 antagonist, GSK-3β inhibitor.

    ≥98%
  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • F1745

    Felodipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • G3353

    Ginkgolic Acid (15:1)

    Found in Ginkgo; HIV protease and fatty acid sy...

    ≥98%
  • I5203

    Inauhzin

    p53 activator, IMPDH and SIRT1 inhibitor.

    ≥98%
  • E5221

    Endothelin-2, human

    Endogenous peptide involved in vascular contrac...

    ≥95%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • L960012

    LY-3214996

    ERK1/2 inhibitor.

    ≥98%