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Chlorpromazine Hydrochloride

Chlorpromazine Hydrochloride

Product ID C2947
Cas No. 69-09-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $77.80 In stock
25 g $108.50 In stock
100 g $325.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chlorpromazine is a phenothiazine that exhibits antipsychotic, antidepressant, anxiolytic, neuroprotective, and anticancer chemotherapeutic activities. Chlorpromazine inhibits D1/2/3/4 receptors, 5-HT1/2 receptors, α1/2-adrenergic receptors, and M1/2 muscarinic acetylcholine receptors (mAChRs). Chlorpromazine stabilizes misfolding motifs of prions, preventing oligomerization. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA). In vivo, chlorpromazine induces autophagy and apoptosis, inhibiting growth of glioma tumors.

Product Info

Cas No.

69-09-0

Purity

≥98%

Formula

C17H19ClN2S • HCl

Formula Wt.

355.33

Chemical Name

2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride

IUPAC Name

3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride

Synonym

Hebanil, Klorpromex, Largactil, Megaphen, Promacid, Chloractil, Sonazine, Marazine, Taroctyl, Torazina

Melting Point

179-180°C(dec.)

Solubility

Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C2947 MSDS PDF

Info Sheet

C2947 Info Sheet PDF

References

Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Shin SY, Lee KS, Choi YK, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. PMID: 23689352.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518-22. PMID: 6108081.

Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011 Oct;23(10):637-645. PMID: 21930594.

Custom Order

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