Chlortetracycline Hydrochloride

Name: Chlortetracycline Hydrochloride
SKU: C2951
Availability: InStock

Product ID C2951

Cas No. 64-72-2

Purity ≥85%

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Description

Chlortetracycline is a tetracycline antibiotic that also exhibits antioxidative, anti-parasitic, and neuroprotective activities. Chlortetracycline binds the 30S subunit of the bacterial ribosome, inhibiting protein synthesis; it also displays antibacterial and antimalarial properties. Additionally, this compound acts as a radical scavenger. In vivo, chlortetracycline suppresses calpain activity and weakly antagonizes NMDA receptor activity and Ca2+ influx, protecting against cerebral ischemia.

Product Info

Cas No.	64-72-2
Purity	≥85%
Formula	C₂₂H₂₃ClN₂O₈ • HCl
Formula Wt.	515.35
Chemical Name	7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2- naphthacenecarboxamide monohydrochloride
IUPAC Name	(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5, 5a-tetrahydrotetracene-2-carboxamide;hydrochloride
Synonym	Aureociclina, Isphamycin.
Melting Point	>210°C (dec)
Solubility	Soluble at about 28oC of: water (13 mg/mL), methanol (17.4mg/mL) or ethanol (1.7mg/mL).
Appearance	Yellow Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C2951 MSDS PDF
Info Sheet	C2951 Info Sheet PDF

References

Nguyen F, Starosta AL, Arenz S, et al. Tetracycline antibiotics and resistance mechanisms. Biol Chem. 2014 May;395(5):559-75. PMID: 24497223.

Kładna A, Michalska T, Berczyński P, et al. Evaluation of the antioxidant activity of tetracycline antibiotics in vitro. Luminescence. 2012 Jul-Aug;27(4):249-55. PMID: 22887986.

Griffin MO, Fricovsky E, Ceballos G, et al. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. PMID: 20592239.

Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.

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Chlortetracycline Hydrochloride

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