LKT Labs

Biochemicals for Life Science Research

Chlortetracycline Hydrochloride

Chlortetracycline Hydrochloride

Product ID C2951
Cas No. 64-72-2
Purity ≥85%
Product Unit SizeCostQuantityStock
5 g $53.00 In stock
25 g $105.00 In stock
100 g $204.00 In stock
Bulk Quote

Quicklinks

Description

Chlortetracycline is a tetracycline antibiotic that also exhibits antioxidative, anti-parasitic, and neuroprotective activities. Chlortetracycline binds the 30S subunit of the bacterial ribosome, inhibiting protein synthesis; it also displays antibacterial and antimalarial properties. Additionally, this compound acts as a radical scavenger. In vivo, chlortetracycline suppresses calpain activity and weakly antagonizes NMDA receptor activity and Ca2+ influx, protecting against cerebral ischemia.

Product Info

Cas No.

64-72-2
Purity

≥85%
Formula

C22H23ClN2O8 • HCl
Formula Wt.

515.35
Chemical Name

7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2- naphthacenecarboxamide monohydrochloride

IUPAC Name

(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5, 5a-tetrahydrotetracene-2-carboxamide;hydrochloride
Synonym

Aureociclina, Isphamycin.
Melting Point

>210°C (dec)
Solubility

Soluble at about 28oC of: water (13 mg/mL), methanol (17.4mg/mL) or ethanol (1.7mg/mL).
Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C2951 MSDS PDF
Info Sheet

C2951 Info Sheet PDF

References

Nguyen F, Starosta AL, Arenz S, et al. Tetracycline antibiotics and resistance mechanisms. Biol Chem. 2014 May;395(5):559-75. PMID: 24497223.

Kładna A, Michalska T, Berczyński P, et al. Evaluation of the antioxidant activity of tetracycline antibiotics in vitro. Luminescence. 2012 Jul-Aug;27(4):249-55. PMID: 22887986.

Griffin MO, Fricovsky E, Ceballos G, et al. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. PMID: 20592239.

Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R3010

    Recombinant Tp-chimeric protein

    Recombinant chimeric protein containing Trepone...

    ≥95%
  • H9661

    Hypocrellin A

    Prevents MHC II antigen presentation.

    ≥77%, contains ~16% B
  • P2817

    Phentolamine Hydrochloride

    ATP-sensitive K+ channel activator, α-adrenerg...

    ≥98%
  • C0375

    Ac-DEVD-pNA

    Caspase 3 substrate.

    ≥95%
  • B4518

    Bleomycin Sulfate

    Mixture of glycopeptide bleomycin sulfate salts...

    ≥90%
  • A0962

    Adrenocorticotropic Hormone (1-4)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • I0902

    Icaritin

    Flavonoid found in Epimedium.

    ≥98%
  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • T3035

    Thienylheptyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • E5477

    Entinostat

    Benzamide; HDAC1 inhibitor.

    ≥98%
  • C5863

    Coptisine Chloride, natural

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • G0106

    Gabapentin

    GABA analog; GABA potentiator, adenosine A1 ago...

    ≥98%
  • R0110

    Ractopamine Hydrochloride

    β1/2-adrenergic agonist.

    ≥97%
  • E6256

    Epothilone A

    Microtubule depolymerization inhibitor.

    ≥95%
  • V3326

    Virginiamycin S1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥99%
  • P3469

    Pirfenidone

    Collagen synthesis inhibitor.

    ≥98%
  • O4104

    Okadaic Acid Sodium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • C4758

    Closantel Sodium

    Protonophore; chitinase OvCHT1 inhibitor.

    ≥98%
  • B6857

    4’-Bromoflavone

    Nrf2-Keap1-ARE complex activator.

    ≥98%
  • T6933

    Trichostatin A

    HDAC inhibitor, mammalian RNA splicing modulato...

    ≥98%