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Cyclocytidine Hydrochloride

Cyclocytidine Hydrochloride

Product ID C9677
Cas No. 10212-25-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $54.20 In stock
5 g $150.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cyclocytidine is a pyrimidine nucleoside analog that inhibits DNA synthesis; it exhibits antiviral and anticancer chemotherapeutic activities. Cyclocytidine induces degranulation of granular tubules in research models. This compound inhibits proliferation of herpes simplex virus (HSV-1) and cytomegalovirus (CMV) in vitro. Previously, cyclocytidine has been used to treat some leukemias, but has since largely been replaced in clinical use.

Product Info

Cas No.

10212-25-6

Purity

≥98%

Formula

C9H11N3O4 • HCl

Formula Wt.

261.66

Chemical Name

2,2'-Anhydro-1-β-D-arabinofuranosylcytosine hydrochloride

IUPAC Name

(2R,3R,3aR,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1, 2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride

Synonym

Ancitabine hydrochloride, O-2,2'-Cyclocytidine monohydrochloride

Melting Point

269-270°C

Solubility

Soluble in water, micro-soluble alcohol.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C9677 MSDS PDF

Info Sheet

C9677 Info Sheet PDF

References

Thomopoulos GN, Garrett JR, Proctor GB. Ultrastructural histochemical studies of secretory granule replenishment in rat submandibular granular tubules after cyclocytidine-induced secretion. J Submicrosc Cytol Pathol. 2002 Jul;34(3):279-89. PMID: 12408361.

Chen Z, Song J, Chen K. Anti-herpes simplex virus action of combined therapy with cyclocytidine and ganciclovir. Zhonghua Yan Ke Za Zhi. 1996 Jan;32(1):25-8. PMID: 8758385.

Nakamura K, Eizuru Y, Kumura K, et al. Antiviral effect of antileukemic drugs N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) and 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine (cyclo-C) against human cytomegalovirus. J Med Virol. 1990 Jun;31(2):141-7. PMID: 1696958.

Movassaghi N, Higgins G, Pyesmany A, et al. Evaluation of cyclocytidine in reinduction and maintenance therapy of children with acute nonlymphocytic leukemia previously treated with cytosine arabinoside: a report from Children's Cancer Study Group. Med Pediatr Oncol. 1984;12(5):352-6. PMID: 6208468.

Custom Order

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