Description
Dehydrocorydaline is an alkaloid compound originally found in Corydalis tubers that exhibits anticancer, anti-inflammatory, and anti-allergic activities. In breast cancer cells, dehydrocorydaline increases activation of caspases 7 and 8, cleavage of poly(ADP)-ribose polymerase (PARP), and the Bax/Bcl-2 ratio, inducing DNA fragmentation and inhibiting proliferation. In macrophages, this compound inhibits LPS-induced increases in IL-6 and IL-1β as well as alterations in the mitochondrial membrane potential. Dehydrocorydaline inhibits passive cutaneous anaphylaxis (type I hypersensitivity), contact dermatitis (type IV hypersensitivity), and mast cell degranulation in animal models of allergies. Additionally, dehydrocorydaline also inhibits acetylcholinesterase (AChE).