• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Dibenzoylmethane, 98%

Dibenzoylmethane, 98%

Product ID D3304
Cas No. 120-46-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $46.20 In stock
25 g $64.90 In stock
100 g $185.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dibenzoylmethane (DBM) is an aromatic 1,3-diketone acetylacetone derivative that is originally found in Glycyrrhiza (licorice). DBM derivatives are very photostable and are often used as sunscreen components; they are also cytoprotective. DBM itself exhibits anti-inflammatory, cytoprotective, anticancer chemotherapeutic, and chemopreventive activities. DBM induces G2/M phase cell cycle arrest and downregulates expression of phospho-rb, cyclin D1, and cyclin A, inhibiting cell proliferation and tumor growth in prostate cancer models; this compound also inhibits the development of intestinal adenoma in vivo. In other models, DBM activates Nrf2-dependent phase II enzymes, inhibiting DNA adduct formation; it also prevents TNF-induced activation of NF-κB.

Product Info

Cas No.

120-46-7

Purity

≥98%

Formula

C15H12O2

Formula Wt.

224.25

Chemical Name

1,3-Diphenyl-1,3-propanedione

IUPAC Name

1,3-diphenylpropane-1,3-dione

Synonym

Phenyl Phenacyl Ketone, γ-Hydroxychalkone

Melting Point

80°C

Solubility

Insoluble in water. Soluble in ether, chloroform, and aqueous NaOH.

Appearance

Slightly yellowish crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3304 MSDS PDF

Info Sheet

D3304 Info Sheet PDF

References

Hegedűs C, Lakatos P, Kiss-Szikszai A, et al. Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death. Pharmacol Res. 2013 Jun;72:25-34. PMID: 23523665.

Anand P, Sung B, Kunnumakkara AB, et al. Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors. Biochem Pharmacol. 2011 Dec 15;82(12):1901-9. PMID: 21924245.

Lin W, Hong JL, Shen G, et al. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm Drug Dispos. 2011 Mar;32(2):65-75. PMID: 21341276.

Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model. Khor TO, Yu S, Barve A, et al. Cancer Res. 2009 Sep 1;69(17):7096-102. PMID: 19706764.

Thimmulappa RK, Rangasamy T, Alam J, et al. Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs. Med Chem. 2008 Sep;4(5):473-81. PMID: 18782044.

Shen G, Khor TO, Hu R, et al. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G6802

    Granisetron Hydrochloride

    5-HT3 antagonist.

    ≥98%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • K3352

    Kinetensin

    Peptide, neurotensin analog.

    ≥95%
  • O9702

    Ozagrel Hydrochloride

    TxA2 synthase inhibitor.

    ≥98%
  • O4532

    Oligomycin B

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • A1616

    AEE-788

    Inhibitor of EGFR, HER2, VEGFR2, and FLT3.

    ≥98%
  • B5874

    Bosutinib

    Src and Abl inhibitor.

    ≥98%
  • A0966

    Adrenocorticotropic Hormone (1-16), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • O7333

    OSI-906

    IGF-1R and InsR inhibitor.

    ≥98%
  • E6398

    EPZ-5676

    DOT1L HMT inhibitor.

    ≥98%
  • N1976

    Netilmicin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • R2711

    Recombinant HCV-Core Antigens

    Recombinant HIV core protein antigen fragment.<...

    ≥95%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy homeo...
    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • Z4900

    ZM-447439 Trihydrate

    AurKA/B inhibitor.

    ≥99%
  • F4518

    Fleroxacin

    Fluoroquinolone; bacterial DNA gyrase and helic...

    ≥98%
  • N1868

    Neratinib

    EGFR inhibitor.

    ≥98%
  • F4679

    Flubendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only