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Doxapram is a respiratory stimulant that acts as an antagonist at K+ channels in isolated type 1 cells. In vitro, doxapram stimulates catecholamine release (preferentially dopamine) from carotid bodies. Additionally, this compound exhibits presynaptic facilatory action and postsynaptic inhibitory action at the neuromuscular junction (NMJ) during NMJ block.
| Cas No. | 7081-53-0 |
|---|---|
| Purity | ≥98% |
| Formula | C24H30N2O2 • HCl • H2O |
| Formula Wt. | 432.98 |
| Chemical Name | 1-ethyl-4-(2-morpholin-4-ylethyl)-3, 3-diphenylpyrrolidin-2-one;hydrate;hydrochloride |
| IUPAC Name | 1-ethyl-4-(2-morpholin-4-ylethyl)-3, 3-diphenylpyrrolidin-2-one;hydrate;hydrochloride |
| Appearance | White to off white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Anderson-Beck R, Wilson L, Brazier S, et al. Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett. 1995 Feb 24;187(1):25-8. PMID: 7617294.
Peers C. Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res. 1991 Dec 24;568(1-2):116-22. PMID: 1667613.
Pollard BJ, Randall NP, Pleuvry BJ. Doxapram and the neuromuscular junction. Br J Anaesth. 1989 Jun;62(6):664-8. PMID: 2751921.