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Ebselen

Ebselen

Product ID E0073
Cas No. 60940-34-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $98.60 In stock
25 mg $225.30 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ebselen is a synthetic glutathione peroxidase mimetic that reacts with cysteine residues; it exhibits antimicrobial, antibacterial, anti-diabetic, and antioxidative activities. Ebselen increases ROS and mitochondrial membrane potential, inhibiting GDH function in vitro. Additionally, ebselen inhibits yeast sporulation and binds the Mycobacterium Ag85 complex, preventing outer membrane synthesis. In diabetic rats, this compound prevents hyperglycemia, decreases glucose levels, Hb1Ac, and oxidative stress, and increases β-cell mass.

Product Info

Cas No.

60940-34-3

Purity

≥99%

Formula

C13H9NOSe

Formula Wt.

274.18

IUPAC Name

2-phenyl-1,2-benzoselenazol-3-one

Synonym

2-Phenyl-1,2-benzisoselenazolin-3-one

Melting Point

180-181°C

Solubility

Soluble in DMSO.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E0073 MSDS PDF

Info Sheet

E0073 Info Sheet PDF

References

Azad GK, Singh V, Mandal P, et al. Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target. FEBS Open Bio. 2014 Jan 6;4:77-89. PMID: 24490132.

Favrot L, Grzegorzewicz AE, Lajiness DH, et al. Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun. 2013;4:2748. PMID: 24193546.

Mahadevan J, Parazzoli S, Oseid E, et al. Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats. Diabetes. 2013 Oct;62(10):3582-8. PMID: 23801580.

Custom Order

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