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Enfuvirtide is a synthetic peptide derived from HIV-1 that exhibits antiviral activity. Enfuvirtide inhibits viral fusion, mimicking the amino acid sequence of gp41, preventing fusion of the virus to the host cell membrane. Enfuvirtide may also induce apoptosis in bystander cells.
| Cas No. | 159519-65-0 |
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| Purity | ≥95% |
| Formula | C204H301N51O64 |
| Formula Wt. | 4462.0 |
| Synonym | T20, Fuzeon, Pentafuside, DP178. |
| Solubility | Best dissolved in alkaline conditions such as sterile pyrogen free 0.1% NaOH, 1% Na2CO3 or disodium phenyl phosphate at a concentration of 0.1-1 mg/mL. Insoluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Tan JJ, Ma XT, Liu C, et al. The current status and challenges in the development of fusion inhibitors as therapeutics for HIV-1 infection. Curr Pharm Des. 2013;19(10):1810-7. PMID: 23092283.
Cai L, Gochin M, Liu K. Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design. Curr Top Med Chem. 2011 Dec;11(24):2959-84. PMID: 22044229.