Enocitabine

Name: Enocitabine
SKU: E5456
Availability: InStock

Product ID E5456

Cas No. 55726-47-1

Purity ≥95%

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Description

Enocitabine is a derivative of cytarabine that acts as a nucleoside analog of cytosine. Enocitabine is the a pro-drug of Ara-C and exhibits anticancer chemotherapeutic and antiviral activities. Like other nucleoside analogs, enocitabine is incorporated into DNA, preventing chain elongation and cell growth. Enocitabine is clinically used in some countries and is undergoing clinical trials in others as a potential treatment for leukemias and lymphomas such as acute myelogenous leukemia (AML). Enocitabine also inhibits replication and growth of cytomegalovirus (CMV).

Product Info

Cas No.	55726-47-1
Purity	≥95%
Formula	C₃₁H₅₅N₃O₆
Formula Wt.	565.78
IUPAC Name	N-[1-[(2R,3S,4S,5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl] docosanamide
Synonym	N4-behenoyl-1-beta-D-arabinofuranosylcytosine, BH-AC
Melting Point	141-142°C
Appearance	Off-white crystalline powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	E5456 MSDS PDF
Info Sheet	E5456 Info Sheet PDF

References

Ito Y, Wakita A, Takada S, et al. Phase 1 trial of gemtuzumab ozogamicin in combination with enocitabine and daunorubicin for elderly patients with relapsed or refractory acute myeloid leukemia: Japan Adult Leukemia Study Group (JALSG)-GML208 study. Int J Hematol. 2012 Oct;96(4):485-91. PMID: 22956429.

Hamada A, Kawaguchi T, Nakano M. Clinical pharmacokinetics of cytarabine formulations. Clin Pharmacokinet. 2002;41(10):705-18. PMID: 12162758.

Nakamura K, Eizuru Y, Kumura K, et al. Antiviral effect of antileukemic drugs N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) and 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine (cyclo-C) against human cytomegalovirus. J Med Virol. 1990 Jun;31(2):141-7. PMID: 1696958.

Maehara Y, Kusumoto T, Kusumoto H, et al. In vitro sensitivity of various human tumors to 1-beta-D-arabinofuranosylcytosine and N4-behenoyl-1-beta-D-arabinofuranosylcytosine. Chemotherapy. 1989;35(3):181-6. PMID: 2766858.

Higashigawa M, Ochiai H, Ohkubo T, et al. Incorporation of N4-behenoyl-1-beta-D-arabinofuranosylcytosine into DNA as 1-beta-D-arabinofuranosylcytosine. Med Oncol Tumor Pharmacother. 1988;5(4):265-71. PMID: 2848163.

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Enocitabine

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