LKT Labs

Biochemicals for Life Science Research

Enocitabine

Enocitabine

Product ID E5456
Cas No. 55726-47-1
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $127.90 In stock
25 mg $265.30 In stock
100 mg $837.20 In stock
250 mg $1,470.10 In stock
Bulk Quote

Quicklinks

Description

Enocitabine is a derivative of cytarabine that acts as a nucleoside analog of cytosine. Enocitabine is the a pro-drug of Ara-C and exhibits anticancer chemotherapeutic and antiviral activities. Like other nucleoside analogs, enocitabine is incorporated into DNA, preventing chain elongation and cell growth. Enocitabine is clinically used in some countries and is undergoing clinical trials in others as a potential treatment for leukemias and lymphomas such as acute myelogenous leukemia (AML). Enocitabine also inhibits replication and growth of cytomegalovirus (CMV).

Product Info

Cas No.

55726-47-1
Purity

≥95%
Formula

C31H55N3O6
Formula Wt.

565.78
IUPAC Name

N-[1-[(2R,3S,4S,5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl] docosanamide
Synonym

N4-behenoyl-1-beta-D-arabinofuranosylcytosine, BH-AC
Melting Point

141-142°C
Appearance

Off-white crystalline powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E5456 MSDS PDF
Info Sheet

E5456 Info Sheet PDF

References

Ito Y, Wakita A, Takada S, et al. Phase 1 trial of gemtuzumab ozogamicin in combination with enocitabine and daunorubicin for elderly patients with relapsed or refractory acute myeloid leukemia: Japan Adult Leukemia Study Group (JALSG)-GML208 study. Int J Hematol. 2012 Oct;96(4):485-91. PMID: 22956429.

Hamada A, Kawaguchi T, Nakano M. Clinical pharmacokinetics of cytarabine formulations. Clin Pharmacokinet. 2002;41(10):705-18. PMID: 12162758.

Nakamura K, Eizuru Y, Kumura K, et al. Antiviral effect of antileukemic drugs N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) and 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine (cyclo-C) against human cytomegalovirus. J Med Virol. 1990 Jun;31(2):141-7. PMID: 1696958.

Maehara Y, Kusumoto T, Kusumoto H, et al. In vitro sensitivity of various human tumors to 1-beta-D-arabinofuranosylcytosine and N4-behenoyl-1-beta-D-arabinofuranosylcytosine. Chemotherapy. 1989;35(3):181-6. PMID: 2766858.

Higashigawa M, Ochiai H, Ohkubo T, et al. Incorporation of N4-behenoyl-1-beta-D-arabinofuranosylcytosine into DNA as 1-beta-D-arabinofuranosylcytosine. Med Oncol Tumor Pharmacother. 1988;5(4):265-71. PMID: 2848163.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T5996

    Tozasertib

    AurK, FLT3, Abl inhibitor.

    ≥98%
  • S1872

    Sesamin

    Lignin found in Sesamin indicum;

    ≥98%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • K5604

    Kobe 0065

    Ras inhibitor.

    ≥99%
  • A6234

    Apigenin

    Flavonoid found in various plant sources; GABA-...

    ≥98%
  • T0095

    Baccatin III

    Diterpene found in Taxus, used to synthesize ta...

    ≥98%
  • B7058

    Brompheniramine Maleate

    Pheniramine derivative; histamine H1 and mAChR ...

    ≥98%
  • A2244

    Aflatoxicol

    Mycotoxin, metabolite of aflatoxin B1 produced ...

    ≥98%
  • O938582

    41-Oxo-rapamycin

    Impurity of rapamycin

    ≥95%
  • I0010

    5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

    Intermediate in the synthesis of purine analogs...

    ≥98%
  • C016481

    Camalexin

    Phytoalexin

    ≥98%
  • H9763

    Hypoxanthine

    Endogenous purine derivative of xanthine.

    ≥98%
  • A5160

    Ampicillin Trihydrate

    β-lactam; transpeptidase inhibitor.

    ≥97%
  • U7354

    Usnic Acid

    Dibenzofuran produced by lichens.

    ≥98%
  • P6800

    Pravastatin Lactone

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • A5373

    Anisomycin

    Peptidyl transferase inhibitor, protein transla...

    ≥98%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • G3253

    8-Gingerol

    Phenol found in Zingiber; 5-HT3 antagonist.

    ≥99%
  • R7680

    Recombinant M. Tuberculosis Antigen TB 38+6+10

    Tuberculosis antigen
  • P7057

    Protodioscin

    Saponin found in Dioscorea; Na+/K+ ATPase and C...

    ≥98%