• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Entinostat

Entinostat

Product ID E5477
Cas No. 209783-80-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $45.30 In stock
5 mg $112.60 In stock
25 mg $323.20 In stock
100 mg $901.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Entinostat is a benzamide derivative that inhibits histone deacetylase 1 (HDAC1); entinostat exhibits anticancer chemotherapeutic, anti-metastatic, and neuroprotective properties. In vitro, entinostat increases transcription of E-cadherin and decreases transcription of N-cadherin, decreasing tubulin-based microtentacles, reversing epithelial-to-mesenchymal transition (EMT) and inhibiting cell migration. In cellular and animal models, this compound upregulates natural killer cell activating receptor NKG2D, increasing the ability of natural killer cells to destroy cancer cells. Additionally, entinostat downregulates cellular FLICE-inhibiting protein (c-FLIP), increasing caspase activation and inducing apoptosis in animal models. Inhibition of HDAC1 in the nucleus accumbens (NAcc) inhibits cocaine-induced plasticity and behavioral changes in rodent models. Entinostat also decreases amyloid-β (Aβ) deposition in the hippocampus and cortex of animal models.

Product Info

Cas No.

209783-80-2

Purity

≥98%

Formula

C21H20N4O3

Formula Wt.

376.41

Chemical Name

N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester

IUPAC Name

pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

Synonym

SNDX-275, MS-275, MS275

Melting Point

159-160°C

Appearance

Yellow Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E5477 MSDS PDF

Info Sheet

E5477 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1335

    Mdivi-1

    Quinazolinone; mitochondrial division inhibitor...

    ≥98%
  • V5254

    Vincristine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥98%
  • I0417

    R-(−)-Iberin

    Sulforaphane homolog, ITC found in cruciferous ...

    ≥98%
  • V0274

    [Lys8]-Vasopressin

    Peptide, vasopressin analog; V1/2 agonist.

    ≥95%
  • U451349

    Ulixertinib

    May induce apoptosis in lymphoma cell lines.

    ≥98%
  • D1722

    Defactinib

    FAK inhibitor.

    ≥98%
  • T3584

    Tivantinib

    MET and GSK-3α/β inhibitor.

    ≥98%
  • E537331

    Enniatin Complex

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • V0160

    Vapreotide

    Synthetic somatostatin analog, peptide; somatos...

    ≥95%
  • T0298

    Tazobactam

    β-lactamase inhibitor.

    ≥98%
  • A9600

    AZD-3463

    ALK and IGF-1R inhibitor.

    ≥99%
  • B1654

    Benzyl Selenocyanate

    Organoselenium compound found in selenium-enric...

    ≥98%
  • P3465

    Piperine

    Alkaloid found in black and long peppers; TRPV1...

    ≥95%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • T7676

    HT-2 Toxin

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC, HPLC
  • S8247

    Sulfasalazine

    Mesalazine derivative, sulfa drug; sepiapterin ...

    ≥98%
  • A4496

    Alyssin

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • E9418

    Exendin 3 (9-39)

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • S1846

    Selumetinib

    MEK1/2 inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only