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Gabexate Mesylate

Gabexate Mesylate

Product ID G0104
Cas No. 56974-61-9
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $155.80 In stock
100 mg $778.60 In stock
250 mg $1,557.20 In stock
Bulk Quote

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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Gabexate displays anticancer chemotherapeutic, anti-angiogenic, anti-inflammatory, and antiviral activities. In vitro, gabexate inhibits the activation of NF-κB, ERK1/2, and Akt, downregulates the production of matrix metalloproteinases 2 and 9, VEGF, and IL-8, and increases expression of protein and phosphatase and tensin homolog (PTEN). Gabexate acts as a proteasome inhibitor, inhibiting activity of tumor-associated trypsinogen and urokinase-type plasminogen activator and decreasing the invasiveness of pancreatic cancer cells. Additionally, gabexate inhibits production of TNF-α, preventing activation of MAPK signaling cascades in vitro. This compound also exhibits antiviral activity against the influenza virus, inhibiting cleavage of hemagglutinin.

Product Info

Cas No.

56974-61-9

Purity

≥99%

Formula

C16H24N3O4 • CH3O3S

Formula Wt.

417.48

Chemical Name

ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;methanesulfonic acid

IUPAC Name

ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;methanesulfonic acid

Synonym

4-[[6-[ (aminoiminomethyl) amino]-1-oxohexyl]oxyl]benzoic acid ethyl ester mesylate salt

Melting Point

90-93℃

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G0104 MSDS PDF

Info Sheet

G0104 Info Sheet PDF

References

Brandi G, Tavolari S, Guarnieri T, et al. Antiprotease strategy in pancreatic cancer treatment: emergence from a preclinical study. Pancreas. 2014 Jan;43(1):53-63. PMID: 24201777.

Hsieh HP, Hsu JT. Strategies of development of antiviral agents directed against influenza virus replication. Curr Pharm Des. 2007;13(34):3531-42. PMID: 18220789.

Uchima Y, Sawada T, Nishihara T, et al. Inhibition and mechanism of action of a protease inhibitor in human pancreatic cancer cells. Pancreas. 2004 Aug;29(2):123-31. PMID: 15257104.

Yuksel M, Okajima K, Uchiba M, et al. Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes. J Pharmacol Exp Ther. 2003 Apr;305(1):298-305. PMID: 12649382.

Aosasa S, Ono S, Mochizuki H, et al. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock. 2001 Feb;15(2):101-5. PMID: 11220636.

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