• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
GDC-0941

GDC-0941

Product ID G124082
Cas No. 957054-30-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $81.70 In stock
25 mg $184.00 In stock
100 mg $511.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0941 is a pan-PI3K inhibitor. When combined with paclitaxel, GDC-0941 exhibits antitumor activity in patients with locally recurrent or metastatic breast cancer. It also increases apoptosis in several cell lines of uveal melanoma in combination with the mTOR inhibitor everolimus.

Product Info

Cas No.

957054-30-7

Purity

≥98%

Formula

C23H27N7O3S2

Formula Wt.

513.64

IUPAC Name

2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)-1-piperazinyl]methyl}-4-(4-morpholinyl)thieno[3,2-d]pyrimidine

Synonym

GNE-0941, Pictilisib, Pictrelisib, RG7321

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G124082 MSDS PDF

Info Sheet

G124082 Info Sheet PDF

References

Folkes A., Ahmadi K., et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 51(18):5522-32 (2008). PMID: 18754654.

Schoffski P., Cresta S., et al. A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer. Breast Cancer Res. 20(1):109 (2018). PMID: 30185228.

Amirouchene-Angelozzi N., Frisch-Dit-Leitz E., et al. The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma. Oncotarget. 7(17):23633-46 (2016). PMID: 26988753.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G062680

    GBR-12909 Dihydrochloride

    Dopamine reuptake inhibitor (DRI).

    ≥98%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • D6108

    1,4-DPCA

    Prolyl hydroxylase inhibitor.

    ≥98%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%
  • I530280

    INH1

    Hec1/Nek2 mitotic pathway inhibitor

    ≥98%
  • H2980

    Humanin, human

    Endogenous peptide; FPRL1/2 agonist.

    ≥95%
  • C002045

    Oxazolidine Cabazitaxel

    Synthesis impurity

    ≥95%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • A5284

    [Val5]-Angiotensin II, human

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • B5753

    Bongkrekic Acid

    Respiratory toxin, mitochondrial permeability t...

    ≥95%
  • R1780

    trans-Retinoic Acid

    Vitamin A carboxylic acid; RAR agonist.

    ≥98%
  • P0278

    Patulin

    Mycotoxin produced by Penicillum and Aspergillu...

    ≥98%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • N0068

    Naringenin

    Flavanone found in species of Citrus. Naringen...

    ≥98%
  • P3461

    Pipemidic Acid

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • C022682

    2-Carbomethoxy-3-thiophenesulfonyl Chloride

    Building block

    ≥98%
  • C8500

    CV-65

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • M0255

    Manzamine A

    Alkaloid found in marine sponges; vacuolar ATPa...

    ≥98%
  • D1643

    Delta Sleep Inducing Peptide

    Peptide; GABA potentiator, NMDA negative allost...

    ≥95%
  • C086007

    CC-671

    TTK/CLK2 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only