• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Gefitinib

Gefitinib

Product ID G1721
Cas No. 184475-35-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $171.30 In stock
250 mg $301.70 In stock
1 g $880.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Gefitinib is an anticancer chemotherapeutic compound that inhibits mutant isoforms of EGFR. Across a variety of cancer cell lines, gefitinib increases poly(ADP)-ribose polymerase (PARP) cleavage and apoptosis, resulting in inhibition of cell growth. Gefitinib also induces expression of PPARγ in cellular models, likely through activation of transcription factor CCAT/enhancer binding protein β (CEBP-β). Gefitinib’s inhibition of EGFR also results in inhibition of heat shock protein 70 (HSP70), which can exacerbate pulmonary fibrosis. Additionally, gefitinib increases phosphorylation of p38 MAPK and JNK, inducing apoptosis in keratinocytes. This compound also promotes differentiation of acute myelogenous leukemia cells in vitro.

Product Info

Cas No.

184475-35-2

Purity

≥98%

Formula

C22H24ClFN4O3

Formula Wt.

446.90

Chemical Name

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

IUPAC Name

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy) quinazolin-4-amine

Melting Point

212-214°C

Solubility

DMSO (20 mg/ml), DMF (20 mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G1721 MSDS PDF

Info Sheet

G1721 Info Sheet PDF

References

Mansure JJ, Nassim R, Chevalier S, et al. A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer. PLoS One. 2013;8(2):e55997. doi: 10.1371/journal.pone.0055997. Erratum in: PLoS One. 2013; 8(5). PMID: 23409107.

Yoshida T, Yamada K, Azuma K, et al. Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysis. Med Oncol. 2013 Mar;30(1):349. PMID: 23263831.

Wan S, Wright DW, Coveney PV. Mechanism of drug efficacy within the EGF receptor revealed by microsecond molecular dynamics simulation. Mol Cancer Ther. 2012 Nov;11(11):2394-400. PMID: 22863610.

Namba T, Tanaka K, Hoshino T, et al. Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS One. 2011;6(11):e27296. PMID: 22096546.

Lu PH, Kuo TC, Chang KC, et al. Gefitinib-induced epidermal growth factor receptor-independent keratinocyte apoptosis is mediated by the JNK activation pathway. Br J Dermatol. 2011 Jan;164(1):38-46. PMID: 20846305.

Stegmaier K, Corsello SM, Ross KN, et al. Gefitinib induces myeloid differentiation of acute myeloid leukemia. Blood. 2005 Oct 15;106(8):2841-8. PMID: 15998836.

Tracy S, Mukohara T, Hansen M, et al. Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res. 2004 Oct 15;64(20):7241-4. PMID: 15492241.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N3478

    Nitrendipine

    Calcium channel blocker.

    ≥98%
  • T7044

    Triamcinolone Acetonide Acetate

    Steroid; glucocorticoid agonist.

    ≥97%
  • J3204

    E-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • S0459

    SB-590885

    B-Raf inhibitor.

    ≥97%
  • P2994

    Physalaemin

    Amphibian tachykinin neuropeptide.

    ≥95%
  • C0243

    Calcitonin Gene Related Peptide (8-37), human

    Calcitonin-family peptide frgament, involved in...

    ≥95%
  • A5225

    α-ANP (1-28), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • M2408

    MGCD-265 Analog

    MET inhibitor.

    ≥98%
  • A3212

    3′-Azido-3′-deoxythymidine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • A4523

    Alfuzosin Hydrochloride

    α1-adrenergic antagonist.

    ≥97%
  • E537333

    Enniatin A1

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • N3301

    Niacin

    Vitamin B, required for formation of NAD and NA...

    ≥98%
  • D1760

    3-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • M1873

    S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • G3455

    Ginsenoside Rc

    Triterpene saponin found in species of Panax; A...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only