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Ginkgolide B

Ginkgolide B

Product ID G3355
Cas No. 15291-77-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $92.00 In stock
25 mg $183.60 In stock
50 mg $347.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginkgolide B is a terpene lactone found in Ginkgo that exhibits anti-atherosclerotic, neuroprotective, neuromodulatory, antioxidative, and anti-inflammatory activities. Ginkgolide B inhibits ATP release from thrombin-activated platelets, downregulates expression of PF4 and CD40L, and decreases phosphorylation of Syk and p38 MAPK, suppressing platelet function in cellular models of atherosclerosis. In neurons, ginkgolide B protects against ischemic injury in a PI3K-dependent manner. Ginkgolide B also inhibits glycine receptors and increases activation of PKA, Ca2+ signaling, and glutamate release. In animal models of cerebral edema, this compound prevents edema and decreases levels of malondialdehyde, activated caspase 3, and PARP and increases levels of superoxide dismutase and glutathione.

Product Info

Cas No.

15291-77-7

Purity

≥98%

Formula

C20H24O10

Formula Wt.

424.40

IUPAC Name

8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione

Melting Point

~300°C

Solubility

Insoluble in water. Soluble in DMSO, acetone, ethanol, ethyl acetate, methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G3355 MSDS PDF

Info Sheet

G3355 Info Sheet PDF

References

Liu X, Yan Y, Bao L, et al. Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. Thromb Res. 2014 Sep 6. [Epub ahead of print]. PMID: 25223809.

Botao Y, Ma J, Xiao W, et al. Protective effect of ginkgolide B on high altitude cerebral edema of rats. High Alt Med Biol. 2013 Mar;14(1):61-4. PMID: 23537262.

Wu X, Qian Z, Ke Y, et al. Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4474-83. PMID: 19602048.

Wang SJ, Chen HH. Ginkgolide B, a constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals. Eur J Pharmacol. 2005 May 9;514(2-3):141-9. PMID: 15910800.

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