LKT Labs

Biochemicals for Life Science Research

Homoharringtonine

Product ID H5750
Cas No. 26833-87-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $58.20 In stock
5 mg $164.40 In stock
10 mg $200.40 In stock
Bulk Quote

Quicklinks

Description

Homoharringtonine is an alkaloid found in Cephalotaxus that binds the A site of the 60 S ribosomal subunit, preventing aminoacyl-tRNA binding, inhibiting protein translation, and inducing cell death; it exhibits anticancer chemotherapeutic and immunosuppressive activities. Homoharringtonine is clinically used to treat chronic myelogenous leukemia (CML) and is currently in clinical trials as a potential treatment for acute myelogenous leukemia (AML) and myelodysplastic syndrome. In clinical subjects, homoharringtonine decreases the number of CD34+, CD117+ cells.

Product Info

Cas No.

26833-87-4
Purity

≥97%
Formula

C29H39NO9
Formula Wt.

545.62
IUPAC Name

1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Melting Point

143-145°C
Solubility

Soluble in DMSO (50 mg/mL), ethanol (25 mg/mL). Slightly soluble in chloroform, methanol.
Appearance

White Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H5750 MSDS PDF
Info Sheet

H5750 Info Sheet PDF
Brochures

Natural Products Booklet

References

Gandhi V, Plunkett W, Cortes JE. Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia. Clin Cancer Res. 2014 Apr 1;20(7):1735-40. PMID: 24501394.

Daver N, Vega-Ruiz A, Kantarjian HM, et al. A phase II open-label study of the intravenous administration of homoharringtonine in the treatment of myelodysplastic syndrome. Eur J Cancer Care (Engl). 2013 Sep;22(5):605-11. PMID: 23701251.

Li YF, Deng Z, Din BH, et al. Effect of homoharringtonine on bone marrow CD34 + CD117 + cells in patients with chronic myelogenous leukemia. Leuk Lymphoma. 2012 May;53(5):934-9. PMID: 22054289.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • K0552

    Kb NB 77-78

    CID-797718 analog; potential PKD1 binding agent...

    ≥98%
  • S336486

    Simeprevir

    NS3/4A inhibitor

    ≥99%
  • A4578

    Altretamine

    DNA alkylator.

    ≥98%
  • E6398

    EPZ-5676

    DOT1L HMT inhibitor.

    ≥98%
  • G3456

    Ginsenoside Rd

    Triterpene saponin found in species of Panax; 2...

    ≥98%
  • T0119

    Taxol Side Chain β-lactam

    Taxol synthesis intermediate.

    ≥98%
  • C1632

    Cefotaxime Acid

    β-lactam cephalosporin; penicillin binding pro...

    ≥91%
  • F334453

    Filipin III

    Antifungal antibiotic

    ≥95%
  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • A0965

    Adrenocorticotropic Hormone (1-14)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • T2817

    Theophylline

    Methylxanthine; PDE inhibitor, A1/2 adenosine a...

    ≥98%
  • S4932

    SMI-4a

    Thiazolidine; Pim kinase inhibitor.

    ≥99%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • G6803

    Granuliberin R

    Antimicrobial peptide found in amphibians.

    ≥95%
  • A2056

    Aflatoxin Q1

    Mycotoxin metabolite

    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%
  • O4400

    Olanzapine

    AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mACh...

    ≥99%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • T2816

    L-Theanine

    Non-essential amino acid found in Camellia and ...

    ≥98%