LKT Labs

Biochemicals for Life Science Research

Homoharringtonine

Product ID H5750
Cas No. 26833-87-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $58.20 In stock
5 mg $164.40 In stock
10 mg $200.40 In stock
Bulk Quote

Quicklinks

Description

Homoharringtonine is an alkaloid found in Cephalotaxus that binds the A site of the 60 S ribosomal subunit, preventing aminoacyl-tRNA binding, inhibiting protein translation, and inducing cell death; it exhibits anticancer chemotherapeutic and immunosuppressive activities. Homoharringtonine is clinically used to treat chronic myelogenous leukemia (CML) and is currently in clinical trials as a potential treatment for acute myelogenous leukemia (AML) and myelodysplastic syndrome. In clinical subjects, homoharringtonine decreases the number of CD34+, CD117+ cells.

Product Info

Cas No.

26833-87-4
Purity

≥97%
Formula

C29H39NO9
Formula Wt.

545.62
IUPAC Name

1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Melting Point

143-145°C
Solubility

Soluble in DMSO (50 mg/mL), ethanol (25 mg/mL). Slightly soluble in chloroform, methanol.
Appearance

White Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H5750 MSDS PDF
Info Sheet

H5750 Info Sheet PDF
Brochures

Natural Products Booklet

References

Gandhi V, Plunkett W, Cortes JE. Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia. Clin Cancer Res. 2014 Apr 1;20(7):1735-40. PMID: 24501394.

Daver N, Vega-Ruiz A, Kantarjian HM, et al. A phase II open-label study of the intravenous administration of homoharringtonine in the treatment of myelodysplastic syndrome. Eur J Cancer Care (Engl). 2013 Sep;22(5):605-11. PMID: 23701251.

Li YF, Deng Z, Din BH, et al. Effect of homoharringtonine on bone marrow CD34 + CD117 + cells in patients with chronic myelogenous leukemia. Leuk Lymphoma. 2012 May;53(5):934-9. PMID: 22054289.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S6168

    Spirapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • T6832

    Triamcinolone Acetonide

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • T0093

    2′-Acetyltaxol

    Taxane synthesis intermediate.

    ≥98%
  • P3542

    PIK-93

    p110α and p110γ PI3K inhibitor.

    ≥98%
  • H9726

    Hygromycin B

    Protein translocation inhibitor.

    ≥95.0%
  • B8176

    2-n-Butylthiophene

    Sulfur analog of furan found in cooked meat pro...

    ≥98%
  • N8277

    Nutlin-3

    Imidzoline derivative; MDM2 inhibitor.

    ≥95%
  • C7997

    C-Type Natriuretic Peptide (1-22), human

    Endogenous cardiomodulatory peptide; NPR-B agon...

    ≥95%
  • C1878

    Cetrimide

    Mixture of quaternary ammonium salts, cationic ...

    ≥98%
  • R3449

    Rimonabant Hydrochloride

    CB1 inverse agonist.

    ≥98%
  • P3561

    Piperlongumine

    Found in Piper longum; TxA2 antagonist, ubiquit...

    ≥98%
  • R1780

    trans-Retinoic Acid

    Vitamin A carboxylic acid; RAR agonist.

    ≥98%
  • D1850

    Demethoxycurcumin

    Curcumin derivative; AMPK activator, STAT3 and ...

    ≥98%
  • S0049

    Salmon Calcitonin Acetate

    Peptide, involved in feeding behavior and insul...

    ≥95%
  • O4917

    Omeprazole

    H+/K+ ATPase inhibitor.

    ≥98%
  • I7746

    1-Isothiocyanato-7-(methylsulfenyl)-heptane

    ITC, erucin analog.

    ≥98%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • G1853

    Genipin

    Iridoid glycoside found in Gardinia jasminoides...

    ≥99%
  • O0400

    Obatoclax

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥98%
  • M4455

    MLN-2238

    Proteasome inhibitor, miR33b modulator.

    ≥95%