Homoharringtonine

Name: Homoharringtonine
SKU: H5750
Availability: InStock

Product ID H5750

Cas No. 26833-87-4

Purity ≥97%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Homoharringtonine is an alkaloid found in Cephalotaxus that binds the A site of the 60 S ribosomal subunit, preventing aminoacyl-tRNA binding, inhibiting protein translation, and inducing cell death; it exhibits anticancer chemotherapeutic and immunosuppressive activities. Homoharringtonine is clinically used to treat chronic myelogenous leukemia (CML) and is currently in clinical trials as a potential treatment for acute myelogenous leukemia (AML) and myelodysplastic syndrome. In clinical subjects, homoharringtonine decreases the number of CD34+, CD117+ cells.

Product Info

Cas No.	26833-87-4
Purity	≥97%
Formula	C₂₉H₃₉NO₉
Formula Wt.	545.62
IUPAC Name	1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Melting Point	143-145°C
Solubility	Soluble in DMSO (50 mg/mL), ethanol (25 mg/mL). Slightly soluble in chloroform, methanol.
Appearance	White Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	H5750 MSDS PDF
Info Sheet	H5750 Info Sheet PDF
Brochures	Natural Products Booklet

References

Gandhi V, Plunkett W, Cortes JE. Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia. Clin Cancer Res. 2014 Apr 1;20(7):1735-40. PMID: 24501394.

Daver N, Vega-Ruiz A, Kantarjian HM, et al. A phase II open-label study of the intravenous administration of homoharringtonine in the treatment of myelodysplastic syndrome. Eur J Cancer Care (Engl). 2013 Sep;22(5):605-11. PMID: 23701251.

Li YF, Deng Z, Din BH, et al. Effect of homoharringtonine on bone marrow CD34 + CD117 + cells in patients with chronic myelogenous leukemia. Leuk Lymphoma. 2012 May;53(5):934-9. PMID: 22054289.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Homoharringtonine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Aflatoxin B1

L-Arginine

A-803467

Tangeretin

ABT-737

1-Isothiocyanato-8-(methylsulfenyl)-octane

Anagrelide

MLN-4924

Fluvoxamine Maleate

RG-108

Ro 20-1724

3-Acetyl-deoxynivalenol

Rosuvastatin Calcium

Cinnarizine

Chondroitin Sulfate, cow

Tobramycin, Free Base

Hydrolyzed Fumonisin B2

Chlorambucil

Chlorpheniramine Maleate

Vardenafil Dihydrochloride

Footer