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Icilin

Icilin

Product ID I0933
Cas No. 36945-98-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $84.10 In stock
10 mg $126.50 In stock
50 mg $523.30 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Icilin is an agonist at transient receptor potential melastatin 8 (TRPM8) channels; it may block transient receptor potential vanilloid 3 (TRPV3) channels. Icilin displays both hyperalgesic and analgesic activities as well as anti-inflammatory and anticancer properties. Activation of TRPM8 channels induces hyperalgesia and allodynia, but long-term activation desensitizes the channels to induce pain relief. Like menthol, icilin acts as a cooling agent, as TRPM8 channels are cold-sensitive. In animal models of colitis, icilin decreases levels of pro-inflammatory cytokines. Icilin inhibits cell motility in pancreatic ductal adenocarcinoma cells and also decreases levels of E2F1 and induces G1 phase cell cycle arrest in prostate cancer cells.

Product Info

Cas No.

36945-98-9

Purity

≥98%

Formula

C16H13N3O4

Formula Wt.

311.3

IUPAC Name

3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyrimidinone

Synonym

AG 3-5

Solubility

Soluble in water (0.1 mg/ml) at 25° C, DMSO:PBS pH 7.2(1:5), DMSO (50 mg/ml), and DMF.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I0933 MSDS PDF

Info Sheet

I0933 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Burgos-Vega CC, Ahn DD, Bischoff C, et al. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache. Cephalalgia. 2015 May 5. [Epub ahead of print]. PMID: 25944818.

Hosoya T, Matsumoto K, Tashima K, et al. TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. Neurogastroenterol Motil. 2014 Aug;26(8):1112-21.PMID: 24832648.

Cucu D, Chiritoiu G, Petrescu S, et al. Characterization of functional transient receptor potential melastatin 8 channels in human pancreatic ductal adenocarcinoma cells. Pancreas. 2014 Jul;43(5):795-800. PMID: 24658318.

Hagenacker T, Lampe M, Schäfers M. Icilin reduces voltage-gated calcium channel currents in naïve and injured DRG neurons in the rat spinal nerve ligation model. Brain Res. 2014 Apr 4;1557:171-9. PMID: 24560602.

Lee S, Chun JN, Kim SH, et al. Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10. PMID: 24239550.

Ramachandran R, Hyun E, Zhao L, et al. TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. PMID: 23596210.

Sherkheli MA, Gisselmann G, Hatt H. Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3. ScientificWorldJournal. 2012;2012:982725. PMID: 22548000.

Custom Order

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