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Isoimperatorin

Isoimperatorin

Product ID I4962
Cas No. 482-45-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $101.00 In stock
25 mg $404.30 In stock
100 mg $1,123.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isoimperatorin is a furocoumarin compound that exhibits anticancer chemotherapeutic, chemopreventive, anti-inflammatory, and antibacterial activities. In vitro, isoimperatorin induces cell cycle arrest at the G2/M phase and inhibits cell proliferation in melanoma cells; separately, it prevents activation of carcinogens such as PBTA-4 and MelQ. In vivo, isoimperatorin decreases tumor growth and tumor weight when combined with UVA irradiation. In cellular models, this compound decreases expression of ROS and vascular cellular adhesion molecule 1 (VCAM-1), increases expression of PPAR-γ, and inhibits NF-κB-induced phosphorylation of Akt, ERK, and PKC. In other cell lines, isoimperatorin inhibits activity of cyclooxygenase (COX-2), preventing production of leukotriene C4 and degranulation of bone marrow-derived mast cells. Additionally, isoimperatorin exhibits activity against both gram positive and gram negative bacteria.

Product Info

Cas No.

482-45-1

Purity

≥98%

Formula

C16H14O4

Formula Wt.

270.28

Chemical Name

4-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

IUPAC Name

4-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

Appearance

Off-white crystals

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I4962 MSDS PDF

Info Sheet

I4962 Info Sheet PDF

References

Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339

Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.

Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.

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