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Itaconic acid is an organic acid that is used as a precursor in the polymer industry. Itaconic acid has been used in production of a surfactant that can increase skin permeation of topical treatments. Itaconic acid has also been used in creation of controlled-release hydrogel antibiotics.
| Cas No. | 97-65-4 |
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| Purity | ≥99% |
| Formula | C5H6O4 |
| Formula Wt. | 130.10 |
| Chemical Name | 2-methylidenebutanedioic acid |
| IUPAC Name | 2-methylidenebutanedioic acid |
| Synonym | Methylenesuccinic acid |
| Solubility | Soluble in water to 100 mM and in ethanol |
| Appearance | Off-white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Abruzzo A, Armenise A, Bigucci F, et al. Surfactants from itaconic acid: toxicity to HaCaT keratinocytes in vitro, micellar solubilization, and skin permeation enhancement of hydrocortisone. Int J Pharm. 2017 May 30;524(1-2):9-15. PMID: 28356226.
Sood S, Gupta VK, Agarwal S, et al. Controlled release of antibiotic amoxicillin drug using carboxymethyl cellulose-cl-poly(lactic acid-co-itaconic acid) hydrogel. Int J Biol Macromol. 2017 Aug;101:612-620. PMID: 28344094.