LKT Labs

Biochemicals for Life Science Research

Kenpaullone

Product ID K1655
Cas No. 142273-20-9
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $75.00 In stock
5 mg $195.00 In stock
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Description

Kenpaullone is an inhibitor of GSK-3β, HGK, and CDKs that exhibits anti-inflammatory, immunomodulatory, and neuroprotective activities. Kenpaullone increases levels of SREBP-1 as well as GIRK-4 and acetylcholine-activated inwardly rectifying K+ (IKACh) channels in diabetic mice. Kenpaullone also inhibits TGF-β-induced induction of RORγt and increases expression of Foxp3 in T cells, inhibiting pathology of experimental autoimmune encephalitis (EAE) in vivo. In pluripotent stem cells derived from autotrophic lateral sclerosis (ALS) patients, kenpaullone improves motor neuron survival. Additionally, this compound inhibits MPP+-induced cell death in cellular models of Parkinson’s disease by preventing changes in the mitochondrial membrane potential and inhibiting activation of caspases.

Product Info

Cas No.

142273-20-9
Purity

≥95%
Formula

C16H11BrN2O
Formula Wt.

327.18
Chemical Name

9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
IUPAC Name

9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Melting Point

>330°C
Solubility

Soluble in DMSO. Insoluble in water and ethanol.

Appearance

Light brown powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

K1655 MSDS PDF
Info Sheet

K1655 Info Sheet PDF

References

Zhang Y, Welzig CM, Picard KL, et al. Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic akita mice. Diabetes. 2014 Jun;63(6):2097-113. PMID: 24458356.

Yoshida H, Kotani H, Kondo T, et al. CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice. Biochem Biophys Res Commun. 2013 Jun 7;435(3):378-84. PMID: 23665028.

Yang YM, Gupta SK, Kim KJ, et al. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 6;12(6):713-26. PMID: 23602540.

Petit-Paitel A, Brau F, Cazareth J, et al. Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons. PLoS One. 2009;4(5):e5491. PMID: 19430525.

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