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Ketanserin

Ketanserin

Product ID K1678
Cas No. 74050-98-9
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $263.00 In stock
500 mg $788.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ketanserin is an inhibitor of 5-HT2A receptors that exhibits antihypertensive, vasodilatory, analgesic, and pro-angiogenic activities. In animal models of hypertension, ketanserin decreases blood pressure and improves baroreceptor sensitivity and vagal tonic activity, improving left ventricular remodeling and overall cardiac function. In animal models of myocardial infarction, ketanserin increases expression of VEGF and increases capillary density in myocardial tissue. In other animal models, this compound inhibits transient receptor potential vanilloid 1 (TRPV1) channel-evoked thermal hyperalgesia. Through downstream targets, ketanserin may also inhibit α1-adrenergic receptors.

Product Info

Cas No.

74050-98-9

Purity

≥97%

Formula

C22H22F3O3

Formula Wt.

395.43

Chemical Name

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione

IUPAC Name

3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione

Synonym

Perketan, Serefrex, Ketensin

Melting Point

227-235°C

Appearance

Almost White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

K1678 MSDS PDF

Info Sheet

K1678 Info Sheet PDF

References

Yu JG, Zhang EH, Liu AJ, et al. Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function. Acta Pharmacol Sin. 2013 Dec;34(12):1508-14. PMID: 24241347.

Loyd DR, Chen PB, Hargreaves KM. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat. Neuroscience. 2012 Feb 17;203:207-15. PMID: 22209919.

van Zwieten PA, Blauw GJ, van Brummelen P. Serotonergic receptors and drugs in hypertension. Pharmacol Toxicol. 1992 Jun;70(6 Pt 2):S17-22. PMID: 1354865.

Koss MC. Mechanism of ketanserin-induced sympatho-inhibition. Eur J Pharmacol. 1991 Mar 5;194(2-3):161-6. PMID: 1676374.

Kato S, Matsuda N, Matsumoto K, et al. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Pharmacol Res. 2012 Sep;66(3):226-234. PMID: 22699012.

Custom Order

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