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L-Tetrahydropalmatine

L-Tetrahydropalmatine

Product ID T1676
Cas No. 483-14-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $82.70 In stock
500 mg $297.60 In stock
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Description

L-Tetrahydropalmatine is an alkaloid found in Corydalis and Stephania that exhibits analgesic, antidepressant, anxiolytic, cardioprotective, and neuromodulatory activities. L-Tetrahydropalmatine is the more active isomer of tetrahydropalmatine; it inhibits D1/2 receptors and suppresses reward and reinforcement signaling in animal models of substance abuse. L-Tetrahydropalmatine also increases time spent in open arms and decreases grooming behavior and immobility in various assays of anxiety and depression in vivo. Additionally, L-tetrahydropalmatine inhibits oxaliplatin-induced neuropathic pain in animal models. In animal models of myocardial ischemia/reperfusion, this compound decreases levels of NO and TNF-α, suppresses myeloperoxidase activity, and increases HIF-1α and VEGF levels.

Product Info

Cas No.

483-14-7

Purity

≥98%

Formula

C21H25NO4

Formula Wt.

355.43

Chemical Name

5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H- dibenzo[a,g]quinolizine

IUPAC Name

(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2, 1-b]isoquinoline

Synonym

(-)-Tetrahydropalmatine, Gindarine, Rotundine, Caseanine, 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)-,13aa-Berbine, 2,3,9,10-tetramethoxy- (8CI), 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (S)-, Cyclanoline, O,O-dimethyl-N-demethyl- (6CI), Gindarine (7CI), (-)-2,3,9,10-Tetramethoxyberbine, (-)-Corydalis B, (-)-Rotundine, (-)-S-Tetrahydropalmatine, (-)-Tetrahydropalmatine, (S)-Tetrahydropalmatine, Caseanine, Hyndarine, N-Demethyl-O,O'-dimethylcyclanoline, N-Demethyl-O,O'-dimethylsteponine, Palmatine, tetrahydro-, (-)-, Rotundine, Rotundine (Stephania), (-)-, l-Tetrahydropalmatine

Melting Point

147°C

Solubility

DMSO

Appearance

White yellowish crystalline

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1676 MSDS PDF

Info Sheet

T1676 Info Sheet PDF

References

Lee B, Sur B, Yeom M, et al. L-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in rats. Biomol Ther (Seoul). 2014 May;22(3):213-22. PMID: 25009702.

Guo Z, Man Y, Wang X, et al. Levo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice. Sci Rep. 2014 Jan 28;4:3905. PMID: 24469566.

Su HL, Zhu J, Chen YJ, et al. Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior. Physiol Behav. 2013 Jun 13;118:195-200. PMID: 23711566.

Han Y, Zhang W, Tang Y, et al. l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS One. 2012;7(6):e38627. PMID: 22715398.

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