• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Lappaconitine

Lappaconitine

Product ID L0060
Cas No. 32854-75-4
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $78.10 In stock
25 mg $191.10 In stock
100 mg $572.90 In stock
500 mg $1,577.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lappaconitine is an alkaloid originally found in species of Aconitum that exhibits analgesic, antinociceptive, anti-inflammatory, anti-arrhythmic, and antiepileptic/anticonvulsant activities. Lappaconitine increases pain threshold and downregulates expression of P2X3 receptors in dorsal root ganglion (DRG) neurons in models of chronic constrictive injury. Lappaconitine also inhibits paw and ear edema in vivo. In vitro, this compound inhibits excitability of hippocampal pyramidal cells and decreases epileptiform burst duration. Additionally, lappaconitine displays class I anti-arrhythmic activity, inducing negative inotropic activity in vivo and inhibiting human heart Na+ channels by binding at neurotoxin site 2.

Product Info

Cas No.

32854-75-4

Purity

≥95%

Formula

C32H44N2O8

Formula Wt.

584.70

Chemical Name

(1α,14α,16β)-20-Ethyl-1,14,16-trimethoxyaconitane- 4,8,9-triol 4-[2-(acetylamino)-benzoate]

IUPAC Name

[(1S,2S,3S,4S,5R,6S,8S,9R,13S,16S,17S)-11-ethyl-3,8-dihydroxy-4,6,16-trimethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl] 2-acetamidobenzoate

Synonym

(+)-Lappaconitine

Melting Point

217-218°C

Solubility

Soluble in benzene. Slightly soluble in alcohol and ether. Practically insoluble in water.

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

L0060 MSDS PDF

Info Sheet

L0060 Info Sheet PDF

References

Ou S, Zhao YD, Xiao Z, et al. Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion. Neurochem Int. 2011 Apr;58(5):564-73. PMID: 21272608.

Wang YZ, Xiao YQ, Zhang C, et al. Study of analgesic and anti-inflammatory effects of lappaconitine gelata. J Tradit Chin Med. 2009 Jun;29(2):141-5. PMID: 19663103.

Wright SN. Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol. 2001 Feb;59(2):183-92. PMID: 11160852.

Heubach JF, Schüle A. Cardiac effects of lappaconitine and N-deacetyllappaconitine, two diterpenoid alkaloids from plants of the Aconitum and Delphinium species. Planta Med. 1998 Feb;64(1):22-6. PMID: 9491764.

Ameri A, Gleitz J, Peters T. Bicuculline-induced epileptiform activity in rat hippocampal slices: suppression by Aconitum alkaloids. Planta Med. 1997 Jun;63(3):228-32. PMID: 9225604.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • L1785

    Levofloxacin Hemihydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥98%
  • I4659

    Iloperidone

    Benzisoxazole phenylethanone; D2 and 5-HT2A ant...

    ≥99%
  • S8169

    Suramin Hexasodium

    RyR agonist, SIRT, telomerase, P2Y, GPCR inhibi...

    ≥98%
  • B8071

    3-tert-Butyl-4-Hydroxyanisole

    BHA derivative, antioxidative food and cosmetic...

    ≥99% Single isomer
  • H9802

    Hyaluronic Acid Sodium (7-10 kDA)

    Glycosaminoglycan

  • O7332

    OSI-027

    mTOR inhibitor.

    ≥99%
  • G7241

    GSK-461364

    PLK1 inhibitor.

    ≥99%
  • T5611

    δ-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • T2800

    Thalidomide

    Immunomodulator; teratogen.

    ≥98%
  • Y4800

    YM-155

    Survivin inhibitor.

    ≥99%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • A5170

    Amrinone

    Pyridine; PDE3 inhibitor.

    ≥98%
  • T9968

    Tyrphostin A25

    SK K+ channel blocker, EGFR inhibitor.

    ≥98%
  • A464768

    Altertoxin 1

    Mycotoxin contaminant in food and feed.

    ≥97%
  • N3452

    Nimustine Hydrochloride

    Nitrosourea, DNA cross-linker.

    ≥97%
  • J6400

    (+)-JQ-1

    Triazolothienodiazepine; BRD inhibitor.

    ≥99%
  • E5241

    Met-Enkephalin

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • A528251

    Angiotensin I/II (1-7)(DP-7)

    Peptide fragment

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only