• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Latrunculin B

Latrunculin B

Product ID L0077
Cas No. 76343-94-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $342.70 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Latrunculin B is a thiazolidinone macrolide found in the Red Sea sponge. Latrunculin acts as an actin inhibitor, binding to G-actin and preventing its transition to F-actin and actin polymerization. This action results in inhibition of rhizoid formation in plants and alterations in Ca2+ trafficking in macrophages. Latrunculin B also exhibits anticancer activity; it induces breaks in double-stranded DNA and increases levels of Bax to induce apoptosis in vitro. Additionally, this compound induces actin microfilament destabilization in prostate cancer cells.

Product Info

Cas No.

76343-94-7

Purity

≥98%

Formula

C20H29NO5S

Formula Wt.

395.51

Chemical Name

(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one

IUPAC Name

(4S)-4-[(4Z,8Z,13R,15R)-15-Hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one

Synonym

LAT-B, (+)-latrunculin B

Solubility

Ethanol

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L0077 MSDS PDF

Info Sheet

L0077 Info Sheet PDF

References

Ahn YT, Shin IJ, Kim JM, et al. Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines. Oncol Lett. 2013 Nov;6(5):1383-1389. PMID: 24179529.

Helal MA, Khalifa S, Ahmed S. Differential binding of latrunculins to G-actin: a molecular dynamics study. J Chem Inf Model. 2013 Sep 23;53(9):2369-75. PMID: 23988111.

Kudrimoti S, Ahmed SA, Daga PR, et al. Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity. Bioorg Med Chem. 2009 Nov 1;17(21):7517-22. PMID: 19800245.

Yoshida K, Shimmen T. Involvement of actin filaments in rhizoid morphogenesis of Spirogyra. Physiol Plant. 2009 Jan;135(1):98-107. PMID: 19121103.

Kurilova LS, Krutetskaia ZI, Lebedev OE. Effect of latrunculin B, jasplakinolide and brefeldin A on the store-dependent Ca2+ entry in macrophages. Tsitologiia. 2006;48(10):867-74. PMID: 17162846.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G6802

    Granisetron Hydrochloride

    5-HT3 antagonist.

    ≥98%
  • I0482

    S-(+)-Ibuprofen

    Optically active isomer of ibuprofen, NSAID; CO...

    ≥98%
  • L9701

    LY-450139

    GHS-R1a agonist, γ-secretase inhibitor.

    ≥98%
  • V3476

    Vitamin D2

    Vitamin D prodrug produced by fungi and alfalfa...

    ≥91%
  • L1881

    Leuprolide Acetate

    GnRH analog; GnRH1 agonist.

    ≥95%
  • C0160

    Canrenone

    Metabolite of spironolactone; Na+/K+ ATPase par...

    ≥98%
  • K0022

    K252b

    Staurosporine analog; PKC inhibitor.

    ≥98%
  • C2916

    Chenodeoxycholic Acid

    Endogenous bile acid; FXR agonist.

    ≥98%
  • C0800

    C59

    PORCN inhibitor.

    ≥98%
  • Z2268

    Z-FR-AMC

    Protease substrate.

    ≥95%
  • I7074

    Irsogladine Maleate

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • D3462

    Diphenhydramine Hydrochloride

    Voltage-gated Na+ channel blocker, mAChR antago...

    ≥98%
  • C5863

    Coptisine Chloride, natural

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • S1853

    Senegenin

    Found in Polygata tennifolia.

    ≥98%
  • I530280

    INH1

    Hec1/Nek2 mitotic pathway inhibitor

    ≥98%
  • C0149

    Calcitonin, salmon

    Endogenous neuropeptide hormone, lowers extrace...

    ≥98%
  • L1982

    Leupeptin Hemisulfate

    Protease inhibitor.

    ≥95%
  • C6019

    C-Peptide, human

    Endogenous peptide, connects A and B chains of ...

    ≥95%
  • G1646

    Geldanamycin

    HSP90 inhibitor.

    ≥97%
  • S5976

    Sotalol Hydrochloride

    β-adrenergic antagonist, voltage-gated Na+ and...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only