Latrunculin B

Name: Latrunculin B
SKU: L0077
Availability: InStock

Product ID L0077

Cas No. 76343-94-7

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Latrunculin B is a thiazolidinone macrolide found in the Red Sea sponge. Latrunculin acts as an actin inhibitor, binding to G-actin and preventing its transition to F-actin and actin polymerization. This action results in inhibition of rhizoid formation in plants and alterations in Ca2+ trafficking in macrophages. Latrunculin B also exhibits anticancer activity; it induces breaks in double-stranded DNA and increases levels of Bax to induce apoptosis in vitro. Additionally, this compound induces actin microfilament destabilization in prostate cancer cells.

Product Info

Cas No.	76343-94-7
Purity	≥98%
Formula	C₂₀H₂₉NO₅S
Formula Wt.	395.51
Chemical Name	(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
IUPAC Name	(4S)-4-[(4Z,8Z,13R,15R)-15-Hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
Synonym	LAT-B, (+)-latrunculin B
Solubility	Ethanol

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	L0077 MSDS PDF
Info Sheet	L0077 Info Sheet PDF

References

Ahn YT, Shin IJ, Kim JM, et al. Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines. Oncol Lett. 2013 Nov;6(5):1383-1389. PMID: 24179529.

Helal MA, Khalifa S, Ahmed S. Differential binding of latrunculins to G-actin: a molecular dynamics study. J Chem Inf Model. 2013 Sep 23;53(9):2369-75. PMID: 23988111.

Kudrimoti S, Ahmed SA, Daga PR, et al. Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity. Bioorg Med Chem. 2009 Nov 1;17(21):7517-22. PMID: 19800245.

Yoshida K, Shimmen T. Involvement of actin filaments in rhizoid morphogenesis of Spirogyra. Physiol Plant. 2009 Jan;135(1):98-107. PMID: 19121103.

Kurilova LS, Krutetskaia ZI, Lebedev OE. Effect of latrunculin B, jasplakinolide and brefeldin A on the store-dependent Ca2+ entry in macrophages. Tsitologiia. 2006;48(10):867-74. PMID: 17162846.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Latrunculin B

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Dacomitinib Monohydrate

Amphotericin B

SR1001

CFT-7455

Dihydromethysticin

Indirubin

Ecdysterone

GDC-0941

Oxytetracycline Hydrochloride

Teriparatide Acetate

5-Hydroxytryptophol

Rabeprazole Sodium

Adrenocorticotropic Hormone (4-10), human

Indomethacin

13-Acetyl-9-dihydrobaccatin-III

Plasminogen Activator Inhibitor 1

Ezetimibe

1-Isothiocyanato-7-(methylsulfinyl)-heptane

Fingolimod Hydrochloride

Baloxavir

Footer