Leptin (22-56), human

Product ID L1660

Cas No.

Purity ≥98%

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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Leptin is an endogenous peptide that binds leptin receptors; it is involved in feeding behavior and energy homeostasis. Leptin exhibits anorexigenic, antihypertensive, and neuroprotective activities. Leptin induces secretion of α-melanocyte-stimulating hormone (α-MSH) and gonadotropin-releasing hormone (GnRH). In obese and hypertensive rats, leptin decreases blood pressure. This peptide also inhibits myocardial muscle contractility and modulates bone growth and resorption. Additionally, leptin may be involved in the development of atherosclerosis. In animal models of Alzheimer’s disease, leptin decreases levels of tau and amyloid-β (Aβ), improving cognitive performance.

Product Info

Purity	≥98%
Formula	C₁₇₁H₂₉₈N₅₀O₅₆
Formula Wt.	3950.56
Synonym	OBGRP(22-56), human
Solubility	Insoluble in water. Soluble in 60% acetonitrile containing 0.1% TFA.

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Store Temp	-20°C
Ship Temp	Ambient

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Info Sheet	L1660 Info Sheet PDF

References

Comninos AN, Jayasena CN, Dhillo WS. The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update. 2014 Mar-Apr;20(2):153-74. PMID: 24173881.

Greco SJ, Bryan KJ, Sarkar S, et al. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;19(4):1155-67. PMID: 20308782.

Zhang W, Telemaque S, Augustyniak RA, et al. Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity. J Neuroendocrinol. 2010 Mar;22(3):175-80. PMID: 20059648.

Taleb S, Herbin O, Ait-Oufella H, et al. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2691-8. PMID: 17690315.

Martin A, David V, Malaval L, et al. Opposite effects of leptin on bone metabolism: a dose-dependent balance related to energy intake and insulin-like growth factor-I pathway. Endocrinology. 2007 Jul;148(7):3419-25. PMID: 17431002.

Moynihan AT, Hehir MP, Glavey SV, et al. Inhibitory effect of leptin on human uterine contractility in vitro. Am J Obstet Gynecol. 2006 Aug;195(2):504-9. PMID: 16647683.

Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med. 1999 Apr 20;130(8):671-80. PMID: 10215564.