LKT Labs

Biochemicals for Life Science Research

Levosimendan

Levosimendan

Product ID L1884
Cas No. 141505-33-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $67.60 In stock
100 mg $142.90 In stock
250 mg $224.60 In stock
1 g $714.70 In stock
Bulk Quote

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Description

Levosimendan is a calcium sensitizer that stabilizes troponin C, activates ATP-sensitive K+ channels, and inhibits phosphodiesterases (PDEs). Levosimendan is clinically used to treat heart failure, as it improves cardiac performance and myocardial contractility without increasing oxygen consumption or decreasing preload or afterload. Levosimendan exhibits vasodilatory and cardioprotective activities, improving left ventricular function in animal models of myocardial ischemia/reperfusion.

Product Info

Cas No.

141505-33-1
Purity

≥98%
Formula

C14H12N6O
Formula Wt.

280.28
Chemical Name

Mesoxalonitrile (-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6- oxo-3-pyridazinyl)phenyl)hydrazone
IUPAC Name

2-[[4-[(4R)-4-methyl-6-oxo-4, 5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
Synonym

Simdax
Melting Point

210-214°C
Solubility

Insoluble in water (0.04 mg/ml), soluble in DMSO (>50 mg/ml).
Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

L1884 MSDS PDF
Info Sheet

L1884 Info Sheet PDF

References

Moreira-Costa L, Tavares-Silva M, Almeida-Coelho J, et al. Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction. Eur J Pharmacol. 2024 Mar 5:966:176336. PMID: 38272343.

Pathak A, Lebrin M, Vaccaro A, et al. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther. 2013 Oct;38(5):341-9. PMID: 23594161.

Malmberg M, Vähäsilta T, Saraste A, et al. Intracoronary Levosimendan during Ischemia Prevents Myocardial Apoptosis. Front Physiol. 2012 Feb 14;3:17. PMID: 22347864.

Papp Z, Édes I, Fruhwald S, et al. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159(2):82-7. PMID: 21784540.

Milligan DJ, Fields AM. Levosimendan: calcium sensitizer and inodilator. Anesthesiol Clin. 2010 Dec;28(4):753-60. PMID: 21074750.

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