LKT Labs

Biochemicals for Life Science Research

Levosimendan

Levosimendan

Product ID L1884
Cas No. 141505-33-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $68.00 In stock
100 mg $143.00 In stock
250 mg $225.00 In stock
1 g $715.00 In stock
Bulk Quote

Quicklinks

Description

Levosimendan is a calcium sensitizer that stabilizes troponin C, activates ATP-sensitive K+ channels, and inhibits phosphodiesterases (PDEs). Levosimendan is clinically used to treat heart failure, as it improves cardiac performance and myocardial contractility without increasing oxygen consumption or decreasing preload or afterload. Levosimendan exhibits vasodilatory and cardioprotective activities, improving left ventricular function in animal models of myocardial ischemia/reperfusion.

Product Info

Cas No.

141505-33-1
Purity

≥98%
Formula

C14H12N6O
Formula Wt.

280.28
Chemical Name

Mesoxalonitrile (-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6- oxo-3-pyridazinyl)phenyl)hydrazone
IUPAC Name

2-[[4-[(4R)-4-methyl-6-oxo-4, 5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
Synonym

Simdax
Melting Point

210-214°C
Solubility

Insoluble in water (0.04 mg/ml), soluble in DMSO (>50 mg/ml).
Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

L1884 MSDS PDF
Info Sheet

L1884 Info Sheet PDF

References

Moreira-Costa L, Tavares-Silva M, Almeida-Coelho J, et al. Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction. Eur J Pharmacol. 2024 Mar 5:966:176336. PMID: 38272343.

Pathak A, Lebrin M, Vaccaro A, et al. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther. 2013 Oct;38(5):341-9. PMID: 23594161.

Malmberg M, Vähäsilta T, Saraste A, et al. Intracoronary Levosimendan during Ischemia Prevents Myocardial Apoptosis. Front Physiol. 2012 Feb 14;3:17. PMID: 22347864.

Papp Z, Édes I, Fruhwald S, et al. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159(2):82-7. PMID: 21784540.

Milligan DJ, Fields AM. Levosimendan: calcium sensitizer and inodilator. Anesthesiol Clin. 2010 Dec;28(4):753-60. PMID: 21074750.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O4532

    Oligomycin B

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • M1687

    Mevinolin

    Statin, naturally produced by mushrooms; HMG-Co...

    ≥97%
  • V3476

    Vitamin D2

    Vitamin D prodrug produced by fungi and alfalfa...

    ≥91%
  • T3584

    Tivantinib

    MET and GSK-3α/β inhibitor.

    ≥98%
  • L5822

    Lofexidine Hydrochloride

    α2-adrenergic agonist.

    ≥98%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • M184774

    5-(Methylsulfinyl)pentyl Nitrile

    Synthetic compound related to sulforaphane.

    ≥98%
  • N0262

    Naphazoline Hydrochloride

    α1-adrenergic agonist.

    ≥97%
  • F5766

    Forchlorfenuron

    Synthetic cytokinin, plant growth regulator; fi...

    ≥98%
  • A9602

    Azacitidine

    Nucleoside (cytidine) analog; DNMT inhibitor, p...

    ≥98%
  • K0144

    Kallikrein Inhibitor

    Peptide; serine protease inhibitor.

    ≥95%
  • V720004

    VS-4718

    Focal adhesion kinase (FAK) inhibitor.

    ≥99%
  • E5220

    Enfuvirtide (T-20)

    Synthetic peptide derived from HIV-1; viral fus...

    ≥95%
  • Z161024

    α-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • G1310

    GDC-0349

    mTOR inhibitor.

    ≥98%
  • E6397

    EPZ6438

    Potent and selective inhibitor

    ≥98%
  • C2943

    Chlorogenic Acid (from Eucommia)

    Polyphenol derivative of caffeic acid found in ...

    ≥98%
  • SB5778

    Snake venom – Bothrops neuwiedi diporous

    Snake venom found in Bothrops neuwiedi diporus;...

    ≥98%
  • G3553

    Ginsenoside Rb2

    Triterpene saponin found in species of Panax.

    ≥98%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%