LKT Labs

Biochemicals for Life Science Research

Levosimendan

Levosimendan

Product ID L1884
Cas No. 141505-33-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $67.60 In stock
100 mg $142.90 In stock
250 mg $224.60 In stock
1 g $714.70 In stock
Bulk Quote

Quicklinks

Description

Levosimendan is a calcium sensitizer that stabilizes troponin C, activates ATP-sensitive K+ channels, and inhibits phosphodiesterases (PDEs). Levosimendan is clinically used to treat heart failure, as it improves cardiac performance and myocardial contractility without increasing oxygen consumption or decreasing preload or afterload. Levosimendan exhibits vasodilatory and cardioprotective activities, improving left ventricular function in animal models of myocardial ischemia/reperfusion.

Product Info

Cas No.

141505-33-1
Purity

≥98%
Formula

C14H12N6O
Formula Wt.

280.28
Chemical Name

Mesoxalonitrile (-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6- oxo-3-pyridazinyl)phenyl)hydrazone
IUPAC Name

2-[[4-[(4R)-4-methyl-6-oxo-4, 5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
Synonym

Simdax
Melting Point

210-214°C
Solubility

Insoluble in water (0.04 mg/ml), soluble in DMSO (>50 mg/ml).
Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

L1884 MSDS PDF
Info Sheet

L1884 Info Sheet PDF

References

Moreira-Costa L, Tavares-Silva M, Almeida-Coelho J, et al. Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction. Eur J Pharmacol. 2024 Mar 5:966:176336. PMID: 38272343.

Pathak A, Lebrin M, Vaccaro A, et al. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther. 2013 Oct;38(5):341-9. PMID: 23594161.

Malmberg M, Vähäsilta T, Saraste A, et al. Intracoronary Levosimendan during Ischemia Prevents Myocardial Apoptosis. Front Physiol. 2012 Feb 14;3:17. PMID: 22347864.

Papp Z, Édes I, Fruhwald S, et al. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159(2):82-7. PMID: 21784540.

Milligan DJ, Fields AM. Levosimendan: calcium sensitizer and inodilator. Anesthesiol Clin. 2010 Dec;28(4):753-60. PMID: 21074750.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L589938

    LOXO-195

    Inhibitor of TRK.

    ≥99%
  • P0253

    Panaxadiol

    Triterpene sapongenin found in species of Panax...

    ≥98%
  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • O9302

    Oxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • E7578

    Estramustine

    Nitrogen mustard and estradiol derivative; micr...

    ≥97%
  • C0266

    Capsaicin, natural

    Found in Capsicum; TRPV agonist.

    ≥95%, capsaicinoids content
  • V0244

    Valganciclovir Hydrochloride

    Nucleoside (deoxyguanosine) analog, ganciclovir...

    ≥98%
  • H800010

    HU 308

    Cannabinoid receptor 2 selective agonist.

    ≥98%
  • H9613

    N-(4-Hydroxyphenyl)retinamide

    Retinol (vitamin A) analog, binds RBP4; Des1 in...

    ≥98%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • E6376

    Eptifibatide

    Glycoprotein IIb/IIIa inhibitor.

    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.

    ≥99%
  • A0978

    Actinonin

    Peptide deformylase, MMP meprin A, aminopeptida...

    ≥98%
  • H1648

    Hemorphin-7

    Endogenous opioid peptide derived from the β-c...

    ≥95%
  • S3476

    Sitagliptin Phosphate Monohydrate

    DPP4 inhibitor.

    ≥98%
  • P2994

    Physalaemin

    Amphibian tachykinin neuropeptide.

    ≥95%
  • B3203

    Biapenem

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • K0053

    Kanamycin A Monosulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%
  • L8261

    Lupeol

    Triterpene; potential tyrosinase inhibitor.

    ≥98%