Levosimendan

Name: Levosimendan
SKU: L1884
Availability: InStock

Product ID L1884

Cas No. 141505-33-1

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Levosimendan is a calcium sensitizer that stabilizes troponin C, activates ATP-sensitive K+ channels, and inhibits phosphodiesterases (PDEs). Levosimendan is clinically used to treat heart failure, as it improves cardiac performance and myocardial contractility without increasing oxygen consumption or decreasing preload or afterload. Levosimendan exhibits vasodilatory and cardioprotective activities, improving left ventricular function in animal models of myocardial ischemia/reperfusion.

Product Info

Cas No.	141505-33-1
Purity	≥98%
Formula	C₁₄H₁₂N₆O
Formula Wt.	280.28
Chemical Name	Mesoxalonitrile (-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6- oxo-3-pyridazinyl)phenyl)hydrazone
IUPAC Name	2-[[4-[(4R)-4-methyl-6-oxo-4, 5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile
Synonym	Simdax
Melting Point	210-214°C
Solubility	Insoluble in water (0.04 mg/ml), soluble in DMSO (>50 mg/ml).
Appearance	Yellow Crystalline Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	L1884 MSDS PDF
Info Sheet	L1884 Info Sheet PDF

References

Moreira-Costa L, Tavares-Silva M, Almeida-Coelho J, et al. Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction. Eur J Pharmacol. 2024 Mar 5:966:176336. PMID: 38272343.

Pathak A, Lebrin M, Vaccaro A, et al. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther. 2013 Oct;38(5):341-9. PMID: 23594161.

Malmberg M, Vähäsilta T, Saraste A, et al. Intracoronary Levosimendan during Ischemia Prevents Myocardial Apoptosis. Front Physiol. 2012 Feb 14;3:17. PMID: 22347864.

Papp Z, Édes I, Fruhwald S, et al. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159(2):82-7. PMID: 21784540.

Milligan DJ, Fields AM. Levosimendan: calcium sensitizer and inodilator. Anesthesiol Clin. 2010 Dec;28(4):753-60. PMID: 21074750.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Levosimendan

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Borrelidin

Triflumuron

Sumatriptan Succinate

1,2,3,4,5,6-Hexabromocyclohexane

Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

Hexarelin

Calcitonin Gene Related Peptide (8-37), rat

Emodin

Phenylbutyrate Sodium

Methysticin

Sotalol Hydrochloride

Acetylsalicylic Acid

Ribavirin

OTS-964

AHU-377 Tris Salt

MK-0524

Acarbose

Rivaroxaban

Meropenem Sodium Carbonate

Tetracycline Hydrochloride

Footer