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LX-2343

LX-2343

Product ID L920000
Cas No. 333745-53-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.30 In stock
25 mg $293.20 In stock
100 mg $797.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LX-2343 improves cognitive dysfunction in APP/PS1 transgenic mice through the inhibition of Aβ accumulation and the promotion of Aβ clearance. This anti-amyloid effect shows LX-2343’s potential as a therapy for Alzhimer’s disease. LX-2343 reduces neuronal apoptosis by alleviating oxidative stress and inhibiting JNK/p38 and pro-apoptotic pathways. It also shows activity as a non-ATP competitive GSK-3β inhibitor.

Product Info

Cas No.

333745-53-2

Purity

≥98%

Formula

C22H19ClN2O6S

Formula Wt.

474.91

IUPAC Name

N-1,3-Benzodioxol-5-yl-N2-(5-chloro-2-methoxyphenyl)-N2-(phenylsulfonyl)glycinamide

Synonym

LX2343

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L920000 MSDS PDF

Info Sheet

L920000 Info Sheet PDF

References

Guo X., Sun G., et al. Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance. Acta Pharmacol Sin. 37(10):1281-1297 (2016). PMID:27569389.

Guo X., Sung G., et al. LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy. Acta Pharmacol Sin. 38(8):1104-1119 (2017). PMID:28649128.

Custom Order

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